Reepithelialisation and the possible involvement of the transcription factor, basonuclin

Kyoichi Matsuzaki, Hajime Inoue, Norio Kumagai

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

This article briefly summarises the basic mechanism of reepithelialisation and discusses the possible role of the celltype-specific transcription factor, basonuclin. Reepithelialisation is initiated by a signal resulting from the absence of neighbouring cells at the wound edge. Basal cells at the wound edge become flattened and lose their intercellular desmosomes and substratum attachment. The amount of cytoplasmic actinomyosin filaments that insert into the new adhesion complexes is increased, and contraction of those filaments produces cell movement. The epithelial cells at the wound edge migrate on a provisional matrix using the newly expressed integrin receptors. Once reepithelialisation is complete, the epithelial cells revert to the normal phenotype of basal epidermal cells, firmly attach to the newly developed basement membrane zone through hemidesmosomes and resume standard differentiation. Protein synthesis increases in the epidermal cells at the wound edge during reepithelialisation. Active protein synthesis requires accelerated transcription of ribosomal RNA genes. The transcription factor basonuclin binds to the ribosomal RNA gene promoter and increases the transcription of the genes. Therefore, it is speculated that basonuclin in epithelial cells is required in the process of reepithelialisation.

Original languageEnglish
Pages (from-to)135-140
Number of pages6
JournalInternational Wound Journal
Volume1
Issue number2
DOIs
Publication statusPublished - 2004
Externally publishedYes

Fingerprint

Transcription Factors
Epithelial Cells
Wounds and Injuries
rRNA Genes
Hemidesmosomes
Desmosomes
Cytoskeleton
Basement Membrane
Integrins
Cell Movement
Proteins
Phenotype
Genes

Keywords

  • Basonuclin
  • Keratinocyte
  • Reepithelialisation
  • Transcription factor
  • Wound healing

ASJC Scopus subject areas

  • Surgery
  • Dermatology

Cite this

Reepithelialisation and the possible involvement of the transcription factor, basonuclin. / Matsuzaki, Kyoichi; Inoue, Hajime; Kumagai, Norio.

In: International Wound Journal, Vol. 1, No. 2, 2004, p. 135-140.

Research output: Contribution to journalArticle

Matsuzaki, Kyoichi ; Inoue, Hajime ; Kumagai, Norio. / Reepithelialisation and the possible involvement of the transcription factor, basonuclin. In: International Wound Journal. 2004 ; Vol. 1, No. 2. pp. 135-140.
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