TY - JOUR
T1 - Reference intervals of white blood cell parameters for healthy adults in japan
AU - The Japanese Society for Laboratory Hematology subcommittee on Standardization of Blood Cell Morphology (JSLH-SBCM)
AU - Takami, Akiyoshi
AU - Watanabe, Shinichiro
AU - Yamamoto, Yoshikazu
AU - Miyachi, Hayato
AU - Bamba, Yukiharu
AU - Ohata, Masahiko
AU - Mishima, Seiji
AU - Kubota, Hiroshi
AU - Nishiura, Akihiko
AU - Inaba, Tohru
AU - Enomoto, Megumi
AU - Mitsuhashi, Takayuki
AU - Nakanishi, Kayoko
AU - Miura, Reiko
AU - Nonaka, Emi
AU - Shimbo, Kei
AU - Yatomi, Yutaka
AU - Tohyama, Kaoru
N1 - Funding Information:
AT: Ministry of Education, Culture, Sports and Technology of Japan (#18K08343); Ministry of Health, Labour and Welfare of Japan. Role of the Funder/Sponsor: The funders played no role in the study design, data collection, and analysis, the decision to publish or the preparation of the manuscript. We thank all of the participants in the study.
Publisher Copyright:
© 2021 John Wiley & Sons Ltd.
PY - 2021/10
Y1 - 2021/10
N2 - Introduction: While white blood cell (WBC) parameters have been suggested to depend on ethnicity and gender, reference intervals in healthy Asian populations are limited. The present study established reference intervals of WBC parameters for healthy adults in Japan. Methods: A total of 750 healthy adults (447 women and 303 men; 18-67 years old, median 40 years old) at 7 Japanese centers who participated in regular medical checkups entered this study. The WBC parameters were measured using automated hematocytometers and blood film reviews by a manual microscopic examination. Results: The reference intervals of the WBC parameters according to gender in healthy adults were determined. Age-specific decreases in WBC counts of both gender groups and in neutrophil counts of women were noted. Favorable correlations between the hematocytometer and microscopic methods were found in neutrophils, lymphocytes, and eosinophils but not in monocytes or basophils. Conclusion: This study suggests the need to consider gender and age in the clinical use of reference intervals of WBC parameters.
AB - Introduction: While white blood cell (WBC) parameters have been suggested to depend on ethnicity and gender, reference intervals in healthy Asian populations are limited. The present study established reference intervals of WBC parameters for healthy adults in Japan. Methods: A total of 750 healthy adults (447 women and 303 men; 18-67 years old, median 40 years old) at 7 Japanese centers who participated in regular medical checkups entered this study. The WBC parameters were measured using automated hematocytometers and blood film reviews by a manual microscopic examination. Results: The reference intervals of the WBC parameters according to gender in healthy adults were determined. Age-specific decreases in WBC counts of both gender groups and in neutrophil counts of women were noted. Favorable correlations between the hematocytometer and microscopic methods were found in neutrophils, lymphocytes, and eosinophils but not in monocytes or basophils. Conclusion: This study suggests the need to consider gender and age in the clinical use of reference intervals of WBC parameters.
KW - 6-part differential
KW - blood film
KW - reference interval
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U2 - 10.1111/ijlh.13486
DO - 10.1111/ijlh.13486
M3 - Article
C2 - 33586915
AN - SCOPUS:85101451773
VL - 43
SP - 948
EP - 958
JO - International Journal of Laboratory Hematology
JF - International Journal of Laboratory Hematology
SN - 1751-5521
IS - 5
ER -