Refractory acute promyelocytic leukemia successfully treated with combination therapy of arsenic trioxide and tamibarotene: A case report

Minoru Kojima; Daisuke Ogiya; Akifumi Ichiki; Ryujiro Hara; Jun Amaki; Hidetsugu Kawai; Hiroki Numata; Ai Sato; Mitsuki Miyamoto; Rikio Suzuki; Shinichiro Machida; Hiromichi Matsushita; Yoshiaki Ogawa; Hiroshi Kawada; Kiyoshi Ando

doi:10.1016/j.lrr.2016.01.001

Refractory acute promyelocytic leukemia successfully treated with combination therapy of arsenic trioxide and tamibarotene: A case report

Minoru Kojima, Daisuke Ogiya, Akifumi Ichiki, Ryujiro Hara, Jun Amaki, Hidetsugu Kawai, Hiroki Numata, Ai Sato, Mitsuki Miyamoto, Rikio Suzuki, Shinichiro Machida, Hiromichi Matsushita, Yoshiaki Ogawa, Hiroshi Kawada, Kiyoshi Ando

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4 Citations (Scopus)

Abstract

A 40-year-old male developed refractory acute promyelocytic leukemia (APL) after various treatments including all-trans retinoic acid, tamibarotene, arsenic trioxide (As₂O₃), conventional chemotherapy, and autologous peripheral blood stem cell transplantation. We attempted to use both tamibarotene and As₂O₃ as a combination therapy, and he achieved molecular complete remission. Grade 2 prolongation of the QTc interval on the electrocardiogram was observed during the therapy. The combination therapy of As₂O₃ and tamibarotene may be effective and tolerable for treating refractory APL cases who have no treatment options, even when they have previously been treated with tamibarotene and As₂O₃ as a single agent.

Original language	English
Pages (from-to)	11-13
Number of pages	3
Journal	Leukemia Research Reports
Volume	5
DOIs	https://doi.org/10.1016/j.lrr.2016.01.001
Publication status	Published - 2016
Externally published	Yes

ASJC Scopus subject areas

Hematology
Oncology

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10.1016/j.lrr.2016.01.001

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Kojima, M., Ogiya, D., Ichiki, A., Hara, R., Amaki, J., Kawai, H., Numata, H., Sato, A., Miyamoto, M., Suzuki, R., Machida, S., Matsushita, H., Ogawa, Y., Kawada, H., & Ando, K. (2016). Refractory acute promyelocytic leukemia successfully treated with combination therapy of arsenic trioxide and tamibarotene: A case report. Leukemia Research Reports, 5, 11-13. https://doi.org/10.1016/j.lrr.2016.01.001

Kojima, M, Ogiya, D, Ichiki, A, Hara, R, Amaki, J, Kawai, H, Numata, H, Sato, A, Miyamoto, M, Suzuki, R, Machida, S, Matsushita, H, Ogawa, Y, Kawada, H & Ando, K 2016, 'Refractory acute promyelocytic leukemia successfully treated with combination therapy of arsenic trioxide and tamibarotene: A case report', Leukemia Research Reports, vol. 5, pp. 11-13. https://doi.org/10.1016/j.lrr.2016.01.001

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title = "Refractory acute promyelocytic leukemia successfully treated with combination therapy of arsenic trioxide and tamibarotene: A case report",

abstract = "A 40-year-old male developed refractory acute promyelocytic leukemia (APL) after various treatments including all-trans retinoic acid, tamibarotene, arsenic trioxide (As2O3), conventional chemotherapy, and autologous peripheral blood stem cell transplantation. We attempted to use both tamibarotene and As2O3 as a combination therapy, and he achieved molecular complete remission. Grade 2 prolongation of the QTc interval on the electrocardiogram was observed during the therapy. The combination therapy of As2O3 and tamibarotene may be effective and tolerable for treating refractory APL cases who have no treatment options, even when they have previously been treated with tamibarotene and As2O3 as a single agent.",

author = "Minoru Kojima and Daisuke Ogiya and Akifumi Ichiki and Ryujiro Hara and Jun Amaki and Hidetsugu Kawai and Hiroki Numata and Ai Sato and Mitsuki Miyamoto and Rikio Suzuki and Shinichiro Machida and Hiromichi Matsushita and Yoshiaki Ogawa and Hiroshi Kawada and Kiyoshi Ando",

note = "Publisher Copyright: {\textcopyright} 2016 The Authors.",

year = "2016",

doi = "10.1016/j.lrr.2016.01.001",

language = "English",

volume = "5",

pages = "11--13",

journal = "Leukemia Research Reports",

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TY - JOUR

T1 - Refractory acute promyelocytic leukemia successfully treated with combination therapy of arsenic trioxide and tamibarotene

T2 - A case report

AU - Kojima, Minoru

AU - Ogiya, Daisuke

AU - Ichiki, Akifumi

AU - Hara, Ryujiro

AU - Amaki, Jun

AU - Kawai, Hidetsugu

AU - Numata, Hiroki

AU - Sato, Ai

AU - Miyamoto, Mitsuki

AU - Suzuki, Rikio

AU - Machida, Shinichiro

AU - Matsushita, Hiromichi

AU - Ogawa, Yoshiaki

AU - Kawada, Hiroshi

AU - Ando, Kiyoshi

PY - 2016

Y1 - 2016

N2 - A 40-year-old male developed refractory acute promyelocytic leukemia (APL) after various treatments including all-trans retinoic acid, tamibarotene, arsenic trioxide (As2O3), conventional chemotherapy, and autologous peripheral blood stem cell transplantation. We attempted to use both tamibarotene and As2O3 as a combination therapy, and he achieved molecular complete remission. Grade 2 prolongation of the QTc interval on the electrocardiogram was observed during the therapy. The combination therapy of As2O3 and tamibarotene may be effective and tolerable for treating refractory APL cases who have no treatment options, even when they have previously been treated with tamibarotene and As2O3 as a single agent.

AB - A 40-year-old male developed refractory acute promyelocytic leukemia (APL) after various treatments including all-trans retinoic acid, tamibarotene, arsenic trioxide (As2O3), conventional chemotherapy, and autologous peripheral blood stem cell transplantation. We attempted to use both tamibarotene and As2O3 as a combination therapy, and he achieved molecular complete remission. Grade 2 prolongation of the QTc interval on the electrocardiogram was observed during the therapy. The combination therapy of As2O3 and tamibarotene may be effective and tolerable for treating refractory APL cases who have no treatment options, even when they have previously been treated with tamibarotene and As2O3 as a single agent.

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U2 - 10.1016/j.lrr.2016.01.001

DO - 10.1016/j.lrr.2016.01.001

M3 - Article

AN - SCOPUS:84957111662

SN - 2213-0489

VL - 5

SP - 11

EP - 13

JO - Leukemia Research Reports

JF - Leukemia Research Reports

ER -

Refractory acute promyelocytic leukemia successfully treated with combination therapy of arsenic trioxide and tamibarotene: A case report

Abstract

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