Refractory bilateral pneumothoraces complicated with interstitial pneumonitis after bone marrow transplantation

Y. Hoshino, K. Hatake, J. Mimuro, Y. Nakamura, N. Ashizawa, S. Tsunoda, K. Muroi, T. Suda, M. Yoshida, A. Miwa

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We report here a case of 33 year-old-man with refractory bilateral pneumothoraces during the treatment for interstitial pneumonitis 6 months after bone marrow transplantation (BMT). He was diagnosed as having acute myelogenous leukemia (AML) M1. He was treated with chemotherapy, and cerebral irradiation. BMT was performed in August 1989 from a sibling donor whose human leukocyte antigen was matched, ABO blood type mismatched. Preconditioning regimen was cyclophosphamide and total body irradiation (TBI). BMT was successful without major graft versus host disease. Thereafter he complained of respiratory symptom and was admitted on June 14 1990. Computed tomogram (CT) scan showed interstitial and alveolar shadows. We started the treatment against bacterial infection, Pneumocystis carinii, cytomegalovirus (CMV) and against interstitial pneumonitis with bolus dose of steroid. The transbronchial lung biopsy specimen revealed interstitial pneumonitis without typical CMV nor pneumocystis carinii pneumonia. Although a CT scan showed improvement of pneumonitis, bilateral pneumothoraces occurred. The adhesion therapy became successful after the reduction of steroid dosage. A pneumothorax rarely occurs after BMT. In this case it is speculated that TBI might be responsible for interstitial pneumonitis, and the steroid might have inhibited the adhesion therapy of pneumothorax.

Original languageEnglish
Pages (from-to)718-722
Number of pages5
Journal[Rinsho ketsueki] The Japanese journal of clinical hematology
Volume34
Issue number6
Publication statusPublished - 1993 Jun

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Interstitial Lung Diseases
Pneumothorax
Bone Marrow Transplantation
Whole-Body Irradiation
Steroids
Cytomegalovirus
Pneumocystis carinii
Pneumocystis Pneumonia
Graft vs Host Disease
Therapeutics
HLA Antigens
Bacterial Infections
Acute Myeloid Leukemia
Cyclophosphamide
Siblings
Pneumonia
Tissue Donors
Biopsy
Drug Therapy
Lung

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hoshino, Y., Hatake, K., Mimuro, J., Nakamura, Y., Ashizawa, N., Tsunoda, S., ... Miwa, A. (1993). Refractory bilateral pneumothoraces complicated with interstitial pneumonitis after bone marrow transplantation. [Rinsho ketsueki] The Japanese journal of clinical hematology, 34(6), 718-722.

Refractory bilateral pneumothoraces complicated with interstitial pneumonitis after bone marrow transplantation. / Hoshino, Y.; Hatake, K.; Mimuro, J.; Nakamura, Y.; Ashizawa, N.; Tsunoda, S.; Muroi, K.; Suda, T.; Yoshida, M.; Miwa, A.

In: [Rinsho ketsueki] The Japanese journal of clinical hematology, Vol. 34, No. 6, 06.1993, p. 718-722.

Research output: Contribution to journalArticle

Hoshino, Y, Hatake, K, Mimuro, J, Nakamura, Y, Ashizawa, N, Tsunoda, S, Muroi, K, Suda, T, Yoshida, M & Miwa, A 1993, 'Refractory bilateral pneumothoraces complicated with interstitial pneumonitis after bone marrow transplantation', [Rinsho ketsueki] The Japanese journal of clinical hematology, vol. 34, no. 6, pp. 718-722.
Hoshino, Y. ; Hatake, K. ; Mimuro, J. ; Nakamura, Y. ; Ashizawa, N. ; Tsunoda, S. ; Muroi, K. ; Suda, T. ; Yoshida, M. ; Miwa, A. / Refractory bilateral pneumothoraces complicated with interstitial pneumonitis after bone marrow transplantation. In: [Rinsho ketsueki] The Japanese journal of clinical hematology. 1993 ; Vol. 34, No. 6. pp. 718-722.
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