Regeneration-based therapies for spinal cord injuries

Hideyuki Okano, Shinjiro Kaneko, Seiji Okada, Akio Iwanami, Masaya Nakamura, Yoshiaki Toyama

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Although it has been long believed that the damaged central nervous system does not regenerate upon injury, there is an emerging hope for regeneration-based therapy of the damaged central nervous system (CNS) due to the progress of developmental biology and regenerative medicine including stem cell biology. In this review, we have summarized recent studies aimed at the development of regeneration-based therapeutic approaches for spinal cord injuries, including therapy with anti-inflammatory cytokines, transplantation of neural stem/precursor cells and induction of axonal regeneration.

Original languageEnglish
Pages (from-to)68-73
Number of pages6
JournalNeurochemistry International
Volume51
Issue number2-4 SPEC. ISS.
DOIs
Publication statusPublished - 2007 Jul

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Keywords

  • Interleukin-6 (IL-6)
  • Neural stem cells
  • Reactive astrocytes
  • Semaphorin 3A
  • Spinal cord injury (SCI)
  • Stat3

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Cellular and Molecular Neuroscience

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