Regeneration of the central nervous system using endogenous repair mechanisms

Hideyuki Okano, Masanori Sakaguchi, Koichi Ohki, Norihiro Suzuki, Kazunobu Sawamoto

Research output: Contribution to journalReview article

90 Citations (Scopus)

Abstract

Recent advances in developmental and stem cell biology have made regeneration-based therapies feasible as therapeutic strategies for patients with damaged central nervous systems (CNSs), including those with spinal cord injuries, Parkinson disease, or stroke. These strategies can be classified into two approaches: (i) the replenishment of lost neural cells and (ii) the induction of axonal regeneration. The first approach includes the activation of endogenous neural stem cells (NSCs) in the adult CNS and cell transplantation therapy. Endogenous NSCs have been shown to give rise to new neurons after insults, including ischemia, have been sustained; this form of neurogenesis followed by the migration and functional maturation of neuronal cells, as well as the responses of glial cells and the vascular system play crucial roles in endogenous repair mechanisms in damaged CNS tissue. In this review, we will summarize the recent advances in regeneration-based therapeutic approaches using endogenous NSCs, including the results of our own collaborative groups.

Original languageEnglish
Pages (from-to)1459-1465
Number of pages7
JournalJournal of Neurochemistry
Volume102
Issue number5
DOIs
Publication statusPublished - 2007 Sep 1

Keywords

  • Adult neurogenesis
  • Musashi-1
  • Neural stem cells
  • Reactive astrocytes

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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