Regional cerebral glucose utilization is modulated by the dosage of apolipoprotein E type 4 allele and α1-antichymotrypsin type A allele in Alzheimer's disease

M. Higuchi, H. Arai, T. Nakagawa, S. Higuchi, Taro Muramatsu, S. Matsushita, Y. I. Kosaka, M. Itoh, H. Sasaki

Research output: Contribution to journalArticle

Abstract

Twenty patients with Alzheimer's disease (AD) with defined apolipoprotein E (APOE), α1-antichymotrypsin (ACT) and presenilin-1 (PS-1) intronic genotypes were examined to quantify the regional cerebral metabolic rate of glucose (rCMRglc) by using positron emission tomography (PET) and 18F-2-fluoro-2-deoxy-D-glucose (FDG). The frontal rCMRglc was significantly increased in patients with the APOE ε4 allele in a dose-dependent fashion. In contrast, the temporo-parietal rCMRglc was significantly reduced in ACT type A allele (ACT*A) carriers compared with those in non-ACT*A carriers. The PS-1 type 1 intronic allele did not have any significant effects on rCMRglc in any cerebral region. These results suggest that both the APOE and ACT genes may play a distinct role in the progression of AD as monitored by imaging studies of cerebral glucose utilization.

Original languageEnglish
Pages (from-to)33-38
Number of pages6
JournalAlzheimer's Research
Volume4
Issue number1
Publication statusPublished - 1998
Externally publishedYes

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Keywords

  • α-antichymotrypsin
  • Alzheimer's disease
  • Apolipoprotein E
  • Glucose metabolism
  • Positron emission tomography
  • Presenilin-1

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

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