TY - JOUR
T1 - Regular dental visits, periodontitis, tooth loss, and atherosclerosis
T2 - The Ohasama study
AU - Yamada, Sho
AU - Komiyama, Takamasa
AU - Ohi, Takashi
AU - Murakami, Takahisa
AU - Miyoshi, Yoshitada
AU - Endo, Kosei
AU - Hiratsuka, Takako
AU - Hara, Azusa
AU - Satoh, Michihiro
AU - Tatsumi, Yukako
AU - Inoue, Ryusuke
AU - Asayama, Kei
AU - Kikuya, Masahiro
AU - Hozawa, Atsushi
AU - Metoki, Hirohito
AU - Imai, Yutaka
AU - Ohkubo, Takayoshi
AU - Hattori, Yoshinori
N1 - Funding Information:
We are grateful to the residents and staff members of Ohasama town and the staff members of the Hanamaki City Government, Iwate Prefectural Central Hospital Attachment Ohasama Regional Clinical Center (former Ohasama Hospital) for their valuable support on the Ohasama study project. Additionally, we appreciate Dr. Chihiro Kojima’s support with the oral examinations and subsequent assessments. This study was supported by the Grants for Scientific Research, Ministry of Education, Culture, Sports, Science, and Technology, Japan (17H04126, 17K15853, 17K19930, 18K09674, 18K09904, 18K17396, 19K19466, 19H03908, 19K10662, 19K19325, 20K08612, 21K10452, 21K10478, 21H04854, 21K17313, and 21K19670); The internal research grants from Keio University; the Japan Arteriosclerosis Prevention Fund; Grant‐in‐aid from the Ministry of Health, Labor, and Welfare, Japan (H29–Junkankitou–Ippan–003 and 20FA1002); ACRO Incubation Grants of Teikyo University; The Academic Contributions from Pfizer Japan Inc.; Scholarship donations from Chugai Pharmaceutical Co., Ltd., Daiichi Sankyo Co., Ltd.; Research Support from Astellas Pharma Inc. and Takeda Pharmaceutical Co., Ltd.; The Health Care Science Institute Research Grant; and the Health Science Center Research Grant, Takeda Science Foundation.
Funding Information:
We are grateful to the residents and staff members of Ohasama town and the staff members of the Hanamaki City Government, Iwate Prefectural Central Hospital Attachment Ohasama Regional Clinical Center (former Ohasama Hospital) for their valuable support on the Ohasama study project. Additionally, we appreciate Dr. Chihiro Kojima’s support with the oral examinations and subsequent assessments. This study was supported by the Grants for Scientific Research, Ministry of Education, Culture, Sports, Science, and Technology, Japan (17H04126, 17K15853, 17K19930, 18K09674, 18K09904, 18K17396, 19K19466, 19H03908, 19K10662, 19K19325, 20K08612, 21K10452, 21K10478, 21H04854, 21K17313, and 21K19670); The internal research grants from Keio University; the Japan Arteriosclerosis Prevention Fund; Grant-in-aid from the Ministry of Health, Labor, and Welfare, Japan (H29–Junkankitou–Ippan–003 and 20FA1002); ACRO Incubation Grants of Teikyo University; The Academic Contributions from Pfizer Japan Inc.; Scholarship donations from Chugai Pharmaceutical Co., Ltd., Daiichi Sankyo Co., Ltd.; Research Support from Astellas Pharma Inc. and Takeda Pharmaceutical Co., Ltd.; The Health Care Science Institute Research Grant; and the Health Science Center Research Grant, Takeda Science Foundation.
Publisher Copyright:
© 2022 The Authors. Journal of Periodontal Research published by John Wiley & Sons Ltd.
PY - 2022/6
Y1 - 2022/6
N2 - Objective: We aimed to explore the association between regular dental visits and atherosclerosis and between periodontitis, number of remaining teeth, and atherosclerosis among community dwellers in Japan. Background: Few studies have examined the association between regular dental visits, periodontitis, tooth loss, and atherosclerosis in community dwellers in Japan. Methods: The participants of this cross-sectional study included community dwellers aged ≥55 years and residing in Ohasama. Exposure variables were regular dental visits; periodontitis, defined as radiographic alveolar bone loss (BL); the Centers for Disease Control/American Academy of Periodontology (CDC/AAP) classification; and number of remaining teeth. The primary outcome was atherosclerosis, defined as maximum carotid intima-media thickness ≥1.1 mm or confirmation of atheromatous plaque. Results: Of 602 participants, 117 had atherosclerosis. In the multivariate model, compared to those with regular dental visits, the odds ratio (OR) (95% confidence intervals [CIs]) of atherosclerosis among those with the absence of regular dental visits was 2.16 (1.03–4.49). Regarding BL-max, compared with those in the first quartile, ORs (95% CIs) of those in the second, third, and fourth quartiles were 1.15 (0.65–2.30), 0.65 (0.32–1.35), and 1.57 (0.81–3.01), respectively. Regarding CDC/AAP classification, compared to those with no or mild periodontitis, ORs (95% CIs) for those with moderate and severe periodontitis were 2.48 (0.61–10.1) and 4.26 (1.01–17.5), respectively. Regarding the number of remaining teeth, compared to those with ≥20 teeth, ORs (95%CIs) for those with 10–19 and 1–9 teeth were 1.77 (1.004–3.12) and 0.96 (0.52–1.80), respectively. Conclusion: The absence of regular dental visits and presence of periodontitis are associated with atherosclerosis among community dwellers in Japan.
AB - Objective: We aimed to explore the association between regular dental visits and atherosclerosis and between periodontitis, number of remaining teeth, and atherosclerosis among community dwellers in Japan. Background: Few studies have examined the association between regular dental visits, periodontitis, tooth loss, and atherosclerosis in community dwellers in Japan. Methods: The participants of this cross-sectional study included community dwellers aged ≥55 years and residing in Ohasama. Exposure variables were regular dental visits; periodontitis, defined as radiographic alveolar bone loss (BL); the Centers for Disease Control/American Academy of Periodontology (CDC/AAP) classification; and number of remaining teeth. The primary outcome was atherosclerosis, defined as maximum carotid intima-media thickness ≥1.1 mm or confirmation of atheromatous plaque. Results: Of 602 participants, 117 had atherosclerosis. In the multivariate model, compared to those with regular dental visits, the odds ratio (OR) (95% confidence intervals [CIs]) of atherosclerosis among those with the absence of regular dental visits was 2.16 (1.03–4.49). Regarding BL-max, compared with those in the first quartile, ORs (95% CIs) of those in the second, third, and fourth quartiles were 1.15 (0.65–2.30), 0.65 (0.32–1.35), and 1.57 (0.81–3.01), respectively. Regarding CDC/AAP classification, compared to those with no or mild periodontitis, ORs (95% CIs) for those with moderate and severe periodontitis were 2.48 (0.61–10.1) and 4.26 (1.01–17.5), respectively. Regarding the number of remaining teeth, compared to those with ≥20 teeth, ORs (95%CIs) for those with 10–19 and 1–9 teeth were 1.77 (1.004–3.12) and 0.96 (0.52–1.80), respectively. Conclusion: The absence of regular dental visits and presence of periodontitis are associated with atherosclerosis among community dwellers in Japan.
KW - alveolar bone loss
KW - atherosclerosis
KW - epidemiology
KW - periodontitis
KW - regular dental visit
KW - tooth loss
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U2 - 10.1111/jre.12990
DO - 10.1111/jre.12990
M3 - Article
C2 - 35388479
AN - SCOPUS:85127550801
SN - 0022-3484
VL - 57
SP - 615
EP - 622
JO - Journal of Periodontal Research
JF - Journal of Periodontal Research
IS - 3
ER -