Regulation of γδ versus αβ T lymphocyte differentiation by the transcription factor SOX13

Heather J. Melichar, Kavitha Narayan, Sandy O. Der, Yoshiki Hiraoka, Noemie Gardiol, Gregoire Jeannet, Werner Held, Cynthia A. Chambers, Joonsoo Kang

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Abstract

αβ and γδ T cells originate from a common, multipotential precursor population in the thymus, but the molecular mechanisms regulating this lineage-fate decision are unknown. We have identified Sox13 as a γδ-specific gene in the immune system. Using Sox13 transgenic mice, we showed that this transcription factor promotes γδ T cell development while opposing αβ T cell differentiation. Conversely, mice deficient in Sox13 expression exhibited impaired development of γδ cells but not αβ T cells. One mechanism of SOX13 function is the inhibition of signaling by the developmentally important Wnt/T cell factor (TCF) pathway. Our data thus reveal a dominant pathway regulating the developmental fate of these two lineages of T lymphocytes.

Original languageEnglish
Pages (from-to)230-233
Number of pages4
JournalScience
Volume315
Issue number5809
DOIs
Publication statusPublished - 2007 Jan 12

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ASJC Scopus subject areas

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Cite this

Melichar, H. J., Narayan, K., Der, S. O., Hiraoka, Y., Gardiol, N., Jeannet, G., Held, W., Chambers, C. A., & Kang, J. (2007). Regulation of γδ versus αβ T lymphocyte differentiation by the transcription factor SOX13. Science, 315(5809), 230-233. https://doi.org/10.1126/science.1135344