Regulation of γδ versus αβ T lymphocyte differentiation by the transcription factor SOX13

Heather J. Melichar, Kavitha Narayan, Sandy O. Der, Yoshiki Hiraoka, Noemie Gardiol, Gregoire Jeannet, Werner Held, Cynthia A. Chambers, Joonsoo Kang

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

αβ and γδ T cells originate from a common, multipotential precursor population in the thymus, but the molecular mechanisms regulating this lineage-fate decision are unknown. We have identified Sox13 as a γδ-specific gene in the immune system. Using Sox13 transgenic mice, we showed that this transcription factor promotes γδ T cell development while opposing αβ T cell differentiation. Conversely, mice deficient in Sox13 expression exhibited impaired development of γδ cells but not αβ T cells. One mechanism of SOX13 function is the inhibition of signaling by the developmentally important Wnt/T cell factor (TCF) pathway. Our data thus reveal a dominant pathway regulating the developmental fate of these two lineages of T lymphocytes.

Original languageEnglish
Pages (from-to)230-233
Number of pages4
JournalScience
Volume315
Issue number5809
DOIs
Publication statusPublished - 2007 Jan 12

Fingerprint

SOXD Transcription Factors
T-Lymphocytes
TCF Transcription Factors
Thymus Gland
Transgenic Mice
Cell Differentiation
Immune System
Transcription Factors

ASJC Scopus subject areas

  • General

Cite this

Melichar, H. J., Narayan, K., Der, S. O., Hiraoka, Y., Gardiol, N., Jeannet, G., ... Kang, J. (2007). Regulation of γδ versus αβ T lymphocyte differentiation by the transcription factor SOX13. Science, 315(5809), 230-233. https://doi.org/10.1126/science.1135344

Regulation of γδ versus αβ T lymphocyte differentiation by the transcription factor SOX13. / Melichar, Heather J.; Narayan, Kavitha; Der, Sandy O.; Hiraoka, Yoshiki; Gardiol, Noemie; Jeannet, Gregoire; Held, Werner; Chambers, Cynthia A.; Kang, Joonsoo.

In: Science, Vol. 315, No. 5809, 12.01.2007, p. 230-233.

Research output: Contribution to journalArticle

Melichar, HJ, Narayan, K, Der, SO, Hiraoka, Y, Gardiol, N, Jeannet, G, Held, W, Chambers, CA & Kang, J 2007, 'Regulation of γδ versus αβ T lymphocyte differentiation by the transcription factor SOX13', Science, vol. 315, no. 5809, pp. 230-233. https://doi.org/10.1126/science.1135344
Melichar, Heather J. ; Narayan, Kavitha ; Der, Sandy O. ; Hiraoka, Yoshiki ; Gardiol, Noemie ; Jeannet, Gregoire ; Held, Werner ; Chambers, Cynthia A. ; Kang, Joonsoo. / Regulation of γδ versus αβ T lymphocyte differentiation by the transcription factor SOX13. In: Science. 2007 ; Vol. 315, No. 5809. pp. 230-233.
@article{7e5fc6b2357e46d1bf3270f4cbe1f615,
title = "Regulation of γδ versus αβ T lymphocyte differentiation by the transcription factor SOX13",
abstract = "αβ and γδ T cells originate from a common, multipotential precursor population in the thymus, but the molecular mechanisms regulating this lineage-fate decision are unknown. We have identified Sox13 as a γδ-specific gene in the immune system. Using Sox13 transgenic mice, we showed that this transcription factor promotes γδ T cell development while opposing αβ T cell differentiation. Conversely, mice deficient in Sox13 expression exhibited impaired development of γδ cells but not αβ T cells. One mechanism of SOX13 function is the inhibition of signaling by the developmentally important Wnt/T cell factor (TCF) pathway. Our data thus reveal a dominant pathway regulating the developmental fate of these two lineages of T lymphocytes.",
author = "Melichar, {Heather J.} and Kavitha Narayan and Der, {Sandy O.} and Yoshiki Hiraoka and Noemie Gardiol and Gregoire Jeannet and Werner Held and Chambers, {Cynthia A.} and Joonsoo Kang",
year = "2007",
month = "1",
day = "12",
doi = "10.1126/science.1135344",
language = "English",
volume = "315",
pages = "230--233",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5809",

}

TY - JOUR

T1 - Regulation of γδ versus αβ T lymphocyte differentiation by the transcription factor SOX13

AU - Melichar, Heather J.

AU - Narayan, Kavitha

AU - Der, Sandy O.

AU - Hiraoka, Yoshiki

AU - Gardiol, Noemie

AU - Jeannet, Gregoire

AU - Held, Werner

AU - Chambers, Cynthia A.

AU - Kang, Joonsoo

PY - 2007/1/12

Y1 - 2007/1/12

N2 - αβ and γδ T cells originate from a common, multipotential precursor population in the thymus, but the molecular mechanisms regulating this lineage-fate decision are unknown. We have identified Sox13 as a γδ-specific gene in the immune system. Using Sox13 transgenic mice, we showed that this transcription factor promotes γδ T cell development while opposing αβ T cell differentiation. Conversely, mice deficient in Sox13 expression exhibited impaired development of γδ cells but not αβ T cells. One mechanism of SOX13 function is the inhibition of signaling by the developmentally important Wnt/T cell factor (TCF) pathway. Our data thus reveal a dominant pathway regulating the developmental fate of these two lineages of T lymphocytes.

AB - αβ and γδ T cells originate from a common, multipotential precursor population in the thymus, but the molecular mechanisms regulating this lineage-fate decision are unknown. We have identified Sox13 as a γδ-specific gene in the immune system. Using Sox13 transgenic mice, we showed that this transcription factor promotes γδ T cell development while opposing αβ T cell differentiation. Conversely, mice deficient in Sox13 expression exhibited impaired development of γδ cells but not αβ T cells. One mechanism of SOX13 function is the inhibition of signaling by the developmentally important Wnt/T cell factor (TCF) pathway. Our data thus reveal a dominant pathway regulating the developmental fate of these two lineages of T lymphocytes.

UR - http://www.scopus.com/inward/record.url?scp=33846487941&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846487941&partnerID=8YFLogxK

U2 - 10.1126/science.1135344

DO - 10.1126/science.1135344

M3 - Article

C2 - 17218525

AN - SCOPUS:33846487941

VL - 315

SP - 230

EP - 233

JO - Science

JF - Science

SN - 0036-8075

IS - 5809

ER -