Regulation of cortical neuron migration by the reelin signaling pathway

Takao Honda, Kazuma Kobayashi, Katsuhiko Mikoshiba, Kazunori Nakajima

Research output: Contribution to journalReview article

51 Citations (Scopus)

Abstract

Reeler is a mutant mouse with defects in layered structures of the central nervous system, such as the cerebral cortex, hippocampus, and cerebellum, and has been extensively examined for more than half a century. The full-length cDNA for the responsible gene for reeler, reelin, was serendipitously identified, revealing that Reelin encodes a large secreted protein. So far, two Reelin receptors, apolipoprotein E receptor 2 and very low-density lipoprotein receptor, and the cytoplasmic adaptor protein Disabled homolog 1 (Dab1) have been shown to be essential for Reelin signaling. Although a number of downstream cascades of Dab1 have also been reported using various experimental systems, the physiological functions of Reelin in vivo remain controversial. Here, we review recent advances in the understanding of the Reelin-Dab1 signaling pathway in the developing cerebral cortex.

Original languageEnglish
Pages (from-to)1270-1279
Number of pages10
JournalNeurochemical Research
Volume36
Issue number7
DOIs
Publication statusPublished - 2011 Jul 1

Keywords

  • ApoER2
  • Dab1
  • Reeler
  • Reelin
  • VLDLR

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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