Regulation of cytokine signaling and inflammation

Toshitkatsu Hanada, Akihiko Yoshimura

Research output: Contribution to journalArticle

514 Citations (Scopus)

Abstract

Inflammation progresses by the action of pro-inflammatory cytokines, including interleukin-1 (IL-1), the tumor necrosis factor (TNF), gamma-interferon (IFNγ), IL-12, IL-18, and the granulocyte-macrophage colony-stimulating factor, and is resolved by anti-inflammatory cytokines such as IL-4, IL-10, IL-13, IFNα, and the transforming growth factor (TGF)β. The intracellular signal transduction pathways of these cytokines have been studied extensively, and these pathways ultimately activate transcription factors, such as NF-κB, Smad, and STATs. Recently, the negative -feedback regulation of these pathways has been identified. In this review, we provide examples of the relationship between cytokine signal transduction, negative-signal regulation, and inflammatory disease models. Furthermore, we illustrate several approaches for treating inflammatory diseases by modulating extracellular and intracellular signaling pathways.

Original languageEnglish
Pages (from-to)413-421
Number of pages9
JournalCytokine and Growth Factor Reviews
Volume13
Issue number4-5
DOIs
Publication statusPublished - 2002 Aug
Externally publishedYes

Fingerprint

Cytokines
Inflammation
Signal transduction
Signal Transduction
Interleukin-18
Interleukin-13
Transforming Growth Factors
Interleukin-12
Granulocyte-Macrophage Colony-Stimulating Factor
Interleukin-1
Interleukin-4
Interleukin-10
Interferons
Interferon-gamma
Anti-Inflammatory Agents
Transcription Factors
Tumor Necrosis Factor-alpha
Feedback

Keywords

  • Cytokine signaling
  • Inflammation
  • Interleukin

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Regulation of cytokine signaling and inflammation. / Hanada, Toshitkatsu; Yoshimura, Akihiko.

In: Cytokine and Growth Factor Reviews, Vol. 13, No. 4-5, 08.2002, p. 413-421.

Research output: Contribution to journalArticle

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