Regulation of cytokine signaling by the SOCS and Spred family proteins

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Various cytokines are involved in the regulation of the immune system and of hematopoiesis. Most cytokines utilize the so-called JAK-STAT pathway, but others activate the Ras-ERK pathway, which is more important than the STAT pathway for the proliferation of hematopoietic cells. Dysregulation of cytokine signaling can cause a variety of diseases, including allergy, inflammation, and cancer. We have identified two important regulator families involved in cytokine signaling: the SOCS proteins and the Spred proteins. Suppressors of cytokine signaling (SOCS) proteins bind to JAK and to certain receptors, thereby suppressing further signaling events. Spred family proteins interact with Ras and Raf, thereby suppressing ERK activation. Studies have shown that SOCS and Spred proteins are key physiological regulators of immunity, hematopoiesis, and angiogenesis. Evidence is also emerging for the involvement of these proteins in human diseases.

Original languageEnglish
Pages (from-to)73-83
Number of pages11
JournalKeio Journal of Medicine
Volume58
Issue number2
DOIs
Publication statusPublished - 2009 Jun

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Suppressor of Cytokine Signaling Proteins
Cytokines
Hematopoiesis
Proteins
MAP Kinase Signaling System
Immune System
Immunity
Hypersensitivity
Cell Proliferation
Inflammation
Neoplasms

Keywords

  • Cytokine
  • Negative regulation
  • Signal transduction

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Regulation of cytokine signaling by the SOCS and Spred family proteins. / Yoshimura, Akihiko.

In: Keio Journal of Medicine, Vol. 58, No. 2, 06.2009, p. 73-83.

Research output: Contribution to journalArticle

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