Regulation of hematopoiesis and its interaction with stem cell niches

Fumio Arai, Atsushi Hirao, Toshio Suda

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Hematopoietic stem cells (HSCs) are responsible for blood cell production throughout the lifetime of an individual. Interaction of HSCs with their particular microenvironments, known as stem cell niches, is critical for maintaining stem cell properties, including self-renewal capability and ability for differentiation into single and multiple lineages. In the niche, the niche cells produce signaling molecules, extracellular matrix, and cell adhesion molecules and regulate stem cell fates. Long-term bone marrow (BM)-repopulating HSCs recently have been found frequently to exist in the BM trabecular bone surface, and it has been clarified that osteoblasts (OBs) are a critical component for sustaining HSCs. HSCs keep a balance between quiescence and cell division/proliferation in the osteoblastic niche. The specific properties of HSCs are controlled dynamically by signaling of receptor/ligand and cell adhesion molecules produced by OBs.

Original languageEnglish
Pages (from-to)371-376
Number of pages6
JournalInternational Journal of Hematology
Volume82
Issue number5
DOIs
Publication statusPublished - 2005

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Keywords

  • Angiopoietin-1
  • ATM
  • N-cadherin
  • Quiescence
  • Tie2

ASJC Scopus subject areas

  • Hematology

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