Regulation of intestinal IgA responses by dietary palmitic acid and its metabolism

Jun Kunisawa, Eri Hashimoto, Asuka Inoue, Risa Nagasawa, Yuji Suzuki, Izumi Ishikawa, Shiori Shikata, Makoto Arita, Junken Aoki, Hiroshi Kiyono

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Enhancement of intestinal IgA responses is a primary strategy in the development of oral vaccine. Dietary fatty acids are known to regulate host immune responses. In this study, we show that dietary palmitic acid (PA) and its metabolites enhance intestinal IgA responses. Intestinal IgA production was increased in mice maintained on a PA-enriched diet. These mice also showed increased intestinal IgA responses against orally immunized Ag, without any effect on serum Ab responses. We found that PA directly stimulates plasma cells to produce Ab. In addition, mice receiving a PA-enriched diet had increased numbers of IgA-producing plasma cells in the large intestine; this effect was abolished when serine palmitoyltransferase was inhibited. These findings suggest that dietary PA regulates intestinal IgA responses and has the potential to be a diet-derived mucosal adjuvant.

Original languageEnglish
Pages (from-to)1666-1671
Number of pages6
JournalJournal of Immunology
Volume193
Issue number4
DOIs
Publication statusPublished - 2014 Aug 15
Externally publishedYes

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Palmitic Acid
Immunoglobulin A
Diet
Plasma Cells
Serine C-Palmitoyltransferase
Large Intestine
Fatty Acids
Vaccines
Serum

ASJC Scopus subject areas

  • Immunology

Cite this

Kunisawa, J., Hashimoto, E., Inoue, A., Nagasawa, R., Suzuki, Y., Ishikawa, I., ... Kiyono, H. (2014). Regulation of intestinal IgA responses by dietary palmitic acid and its metabolism. Journal of Immunology, 193(4), 1666-1671. https://doi.org/10.4049/jimmunol.1302944

Regulation of intestinal IgA responses by dietary palmitic acid and its metabolism. / Kunisawa, Jun; Hashimoto, Eri; Inoue, Asuka; Nagasawa, Risa; Suzuki, Yuji; Ishikawa, Izumi; Shikata, Shiori; Arita, Makoto; Aoki, Junken; Kiyono, Hiroshi.

In: Journal of Immunology, Vol. 193, No. 4, 15.08.2014, p. 1666-1671.

Research output: Contribution to journalArticle

Kunisawa, J, Hashimoto, E, Inoue, A, Nagasawa, R, Suzuki, Y, Ishikawa, I, Shikata, S, Arita, M, Aoki, J & Kiyono, H 2014, 'Regulation of intestinal IgA responses by dietary palmitic acid and its metabolism', Journal of Immunology, vol. 193, no. 4, pp. 1666-1671. https://doi.org/10.4049/jimmunol.1302944
Kunisawa J, Hashimoto E, Inoue A, Nagasawa R, Suzuki Y, Ishikawa I et al. Regulation of intestinal IgA responses by dietary palmitic acid and its metabolism. Journal of Immunology. 2014 Aug 15;193(4):1666-1671. https://doi.org/10.4049/jimmunol.1302944
Kunisawa, Jun ; Hashimoto, Eri ; Inoue, Asuka ; Nagasawa, Risa ; Suzuki, Yuji ; Ishikawa, Izumi ; Shikata, Shiori ; Arita, Makoto ; Aoki, Junken ; Kiyono, Hiroshi. / Regulation of intestinal IgA responses by dietary palmitic acid and its metabolism. In: Journal of Immunology. 2014 ; Vol. 193, No. 4. pp. 1666-1671.
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