Regulation of stem cells in the niche

Toshio Suda, Fumio Arai, Shigeto Shimmura

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Stem cells have a self-renewal capacity as well as the capacity to differentiate into single or multiple lineages. In this review, we discuss the mechanism of maintenance of "sternness" in hematopoietic systems and refer to our studies of corneal epithelial stem cells. The quiescent state is believed to be indispensable for the maintenance of hematopoietic stem cells (HSC). Interaction of HSC with their particular microenvironments, known as stem cell niches, is critical for the cell cycle regulation of HSC. Monitoring of the quiescence of HSC by a side population (SP) revealed that the cell cycle status of HSC is dynamically controlled by microenvironments. We recently discovered a molecular mechanism by which the cell cycle of HSC is regulated by the niche. HSC expressing tyrosine kinase Tie2 receptors adhere to osteoblasts in the bone marrow (BM) niche. The interaction of Tie2 and its ligand angiopoietin-1 (Ang-1) leads to tight adhesion of HSC to stromal cells, resulting in the maintenance of long-term repopulating activity of HSC. Thus, the Tie2/Ang-1 signaling pathway plays a critical role in maintaining HSC in the quiescent state in the BM niche. Understanding of the relationships of stem cells to their niches should lead to development of new strategies directed toward regeneration.

Original languageEnglish
JournalCornea
Volume24
Issue number8 SUPPL.
Publication statusPublished - 2005 Nov

Fingerprint

Stem Cell Niche
Hematopoietic Stem Cells
Angiopoietin-1
Cell Cycle
Stem Cells
TIE-2 Receptor
Bone Marrow
Side-Population Cells
Maintenance
Hematopoietic System
Receptor Protein-Tyrosine Kinases
Stromal Cells
Osteoblasts
Regeneration
Epithelial Cells
Ligands

Keywords

  • Angiopoietin-1
  • Corneal epithelial stem cell
  • Hematopoietic stem cell
  • Niche
  • ROS
  • Slow cycling
  • Tie2

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Suda, T., Arai, F., & Shimmura, S. (2005). Regulation of stem cells in the niche. Cornea, 24(8 SUPPL.).

Regulation of stem cells in the niche. / Suda, Toshio; Arai, Fumio; Shimmura, Shigeto.

In: Cornea, Vol. 24, No. 8 SUPPL., 11.2005.

Research output: Contribution to journalArticle

Suda, T, Arai, F & Shimmura, S 2005, 'Regulation of stem cells in the niche', Cornea, vol. 24, no. 8 SUPPL..
Suda T, Arai F, Shimmura S. Regulation of stem cells in the niche. Cornea. 2005 Nov;24(8 SUPPL.).
Suda, Toshio ; Arai, Fumio ; Shimmura, Shigeto. / Regulation of stem cells in the niche. In: Cornea. 2005 ; Vol. 24, No. 8 SUPPL.
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