Regulation of Th17 cell differentiation by intestinal commensal bacteria

K. Atarashi; T. Tanoue; Y. Umesaki; K. Honda

doi:10.3920/BM2010.0026

Regulation of Th17 cell differentiation by intestinal commensal bacteria

K. Atarashi, T. Tanoue, Y. Umesaki, K. Honda

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Interleukin (IL)-17-producing CD4 T cells ('Th17 cells') are most abundant at the intestinal mucosa, and play a critical role in the maintenance of mucosal barrier function. Recent studies indicate that accumulation of intestinal Th17 cells depends on stimulation by intestinal commensal bacteria - particularly by segmented filamentous bacterium. In this review, we summarise recent advances in our understanding of the mechanisms of intestinal Th17 synthesis in mice, and discuss their relevance to infectious and inflammatory diseases.

Original language	English
Pages (from-to)	327-334
Number of pages	8
Journal	Beneficial Microbes
Volume	1
Issue number	4
DOIs	https://doi.org/10.3920/BM2010.0026
Publication status	Published - 2010
Externally published	Yes

Keywords

Infectious and inflammatory disease
Interleukin
Mucosal barrier
Th17 synthesis

ASJC Scopus subject areas

Microbiology
Microbiology (medical)

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AU - Honda, K.

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Regulation of Th17 cell differentiation by intestinal commensal bacteria

Abstract

Keywords

ASJC Scopus subject areas

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