Abstract
Interleukin (IL)-17-producing CD4 T cells ('Th17 cells') are most abundant at the intestinal mucosa, and play a critical role in the maintenance of mucosal barrier function. Recent studies indicate that accumulation of intestinal Th17 cells depends on stimulation by intestinal commensal bacteria - particularly by segmented filamentous bacterium. In this review, we summarise recent advances in our understanding of the mechanisms of intestinal Th17 synthesis in mice, and discuss their relevance to infectious and inflammatory diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 327-334 |
| Number of pages | 8 |
| Journal | Beneficial microbes |
| Volume | 1 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2010 |
| Externally published | Yes |
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Keywords
- Infectious and inflammatory disease
- Interleukin
- Mucosal barrier
- Th17 synthesis
ASJC Scopus subject areas
- Microbiology (medical)
- Microbiology
Cite this
Regulation of Th17 cell differentiation by intestinal commensal bacteria. / Atarashi, Koji; Tanoue, Takeshi; Umesaki, Y.; Honda, Kenya.
In: Beneficial microbes, Vol. 1, No. 4, 2010, p. 327-334.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Regulation of Th17 cell differentiation by intestinal commensal bacteria
AU - Atarashi, Koji
AU - Tanoue, Takeshi
AU - Umesaki, Y.
AU - Honda, Kenya
PY - 2010
Y1 - 2010
N2 - Interleukin (IL)-17-producing CD4 T cells ('Th17 cells') are most abundant at the intestinal mucosa, and play a critical role in the maintenance of mucosal barrier function. Recent studies indicate that accumulation of intestinal Th17 cells depends on stimulation by intestinal commensal bacteria - particularly by segmented filamentous bacterium. In this review, we summarise recent advances in our understanding of the mechanisms of intestinal Th17 synthesis in mice, and discuss their relevance to infectious and inflammatory diseases.
AB - Interleukin (IL)-17-producing CD4 T cells ('Th17 cells') are most abundant at the intestinal mucosa, and play a critical role in the maintenance of mucosal barrier function. Recent studies indicate that accumulation of intestinal Th17 cells depends on stimulation by intestinal commensal bacteria - particularly by segmented filamentous bacterium. In this review, we summarise recent advances in our understanding of the mechanisms of intestinal Th17 synthesis in mice, and discuss their relevance to infectious and inflammatory diseases.
KW - Infectious and inflammatory disease
KW - Interleukin
KW - Mucosal barrier
KW - Th17 synthesis
UR - http://www.scopus.com/inward/record.url?scp=82355191456&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=82355191456&partnerID=8YFLogxK
U2 - 10.3920/BM2010.0026
DO - 10.3920/BM2010.0026
M3 - Article
VL - 1
SP - 327
EP - 334
JO - Beneficial microbes
JF - Beneficial microbes
SN - 1876-2883
IS - 4
ER -