Regulation of Th17 cell differentiation by intestinal commensal bacteria

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Interleukin (IL)-17-producing CD4 T cells ('Th17 cells') are most abundant at the intestinal mucosa, and play a critical role in the maintenance of mucosal barrier function. Recent studies indicate that accumulation of intestinal Th17 cells depends on stimulation by intestinal commensal bacteria - particularly by segmented filamentous bacterium. In this review, we summarise recent advances in our understanding of the mechanisms of intestinal Th17 synthesis in mice, and discuss their relevance to infectious and inflammatory diseases.

Original languageEnglish
Pages (from-to)327-334
Number of pages8
JournalBeneficial microbes
Volume1
Issue number4
DOIs
Publication statusPublished - 2010
Externally publishedYes

Fingerprint

Th17 Cells
Cell Differentiation
Bacteria
Interleukin-17
Intestinal Mucosa
Communicable Diseases
Maintenance
T-Lymphocytes

Keywords

  • Infectious and inflammatory disease
  • Interleukin
  • Mucosal barrier
  • Th17 synthesis

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

Regulation of Th17 cell differentiation by intestinal commensal bacteria. / Atarashi, Koji; Tanoue, Takeshi; Umesaki, Y.; Honda, Kenya.

In: Beneficial microbes, Vol. 1, No. 4, 2010, p. 327-334.

Research output: Contribution to journalArticle

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