Regulation of the starfish sperm acrosome reaction by cGMP, pH, cAMP and Ca2+

Midori Matsumoto, Osamu Kawase, M. Sadiqul Islam, Masahiro Naruse, Shin Nosuke Watanabe, Riho Ishikawa, Motonori Hoshi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

In the starfish, Asterias amurensis, three components in the jelly coat of eggs, namely acrosome reaction-inducing substance (ARIS), Co-ARIS and asterosap, act in concert on homologous spermatozoa to induce the acrosome reaction (AR). Molecular recognition between the sperm surface molecules and the egg jelly molecules must underlie signal transduction events triggering the AR. Asterosap is a sperm-activating molecule, which stimulates rapid synthesis of intracellular cGMP, pH and Ca2+. This transient elevation of Ca2+ level is caused by a K+-dependent Na+/Ca2+ exchanger, and the increase of intracellular pH is sufficient for ARIS to induce the AR. The concerted action of ARIS and asterosap could induce elevate intracellular cAMP levels in starfish sperm and the sustained increase in [Ca2+], which is essential for the AR. The signaling pathway induced by these factors seems to be synergistically regulated to trigger the AR in starfish sperm.

Original languageEnglish
Pages (from-to)523-526
Number of pages4
JournalInternational Journal of Developmental Biology
Volume52
Issue number5-6
DOIs
Publication statusPublished - 2008

Fingerprint

Starfish
Acrosome Reaction
Spermatozoa
Asterias
Eggs
Ovum
Signal Transduction

Keywords

  • Cyclic nucleotides
  • Invertebrate fertilization
  • Ion channel
  • Signal transduction
  • Spermatozoa

ASJC Scopus subject areas

  • Developmental Biology
  • Embryology

Cite this

Regulation of the starfish sperm acrosome reaction by cGMP, pH, cAMP and Ca2+ . / Matsumoto, Midori; Kawase, Osamu; Islam, M. Sadiqul; Naruse, Masahiro; Watanabe, Shin Nosuke; Ishikawa, Riho; Hoshi, Motonori.

In: International Journal of Developmental Biology, Vol. 52, No. 5-6, 2008, p. 523-526.

Research output: Contribution to journalArticle

Matsumoto, Midori ; Kawase, Osamu ; Islam, M. Sadiqul ; Naruse, Masahiro ; Watanabe, Shin Nosuke ; Ishikawa, Riho ; Hoshi, Motonori. / Regulation of the starfish sperm acrosome reaction by cGMP, pH, cAMP and Ca2+ In: International Journal of Developmental Biology. 2008 ; Vol. 52, No. 5-6. pp. 523-526.
@article{c57b4d926b314c38b698fde296643915,
title = "Regulation of the starfish sperm acrosome reaction by cGMP, pH, cAMP and Ca2+",
abstract = "In the starfish, Asterias amurensis, three components in the jelly coat of eggs, namely acrosome reaction-inducing substance (ARIS), Co-ARIS and asterosap, act in concert on homologous spermatozoa to induce the acrosome reaction (AR). Molecular recognition between the sperm surface molecules and the egg jelly molecules must underlie signal transduction events triggering the AR. Asterosap is a sperm-activating molecule, which stimulates rapid synthesis of intracellular cGMP, pH and Ca2+. This transient elevation of Ca2+ level is caused by a K+-dependent Na+/Ca2+ exchanger, and the increase of intracellular pH is sufficient for ARIS to induce the AR. The concerted action of ARIS and asterosap could induce elevate intracellular cAMP levels in starfish sperm and the sustained increase in [Ca2+], which is essential for the AR. The signaling pathway induced by these factors seems to be synergistically regulated to trigger the AR in starfish sperm.",
keywords = "Cyclic nucleotides, Invertebrate fertilization, Ion channel, Signal transduction, Spermatozoa",
author = "Midori Matsumoto and Osamu Kawase and Islam, {M. Sadiqul} and Masahiro Naruse and Watanabe, {Shin Nosuke} and Riho Ishikawa and Motonori Hoshi",
year = "2008",
doi = "10.1387/ijdb.072511mm",
language = "English",
volume = "52",
pages = "523--526",
journal = "International Journal of Developmental Biology",
issn = "0214-6282",
publisher = "University of the Basque Country Press",
number = "5-6",

}

TY - JOUR

T1 - Regulation of the starfish sperm acrosome reaction by cGMP, pH, cAMP and Ca2+

AU - Matsumoto, Midori

AU - Kawase, Osamu

AU - Islam, M. Sadiqul

AU - Naruse, Masahiro

AU - Watanabe, Shin Nosuke

AU - Ishikawa, Riho

AU - Hoshi, Motonori

PY - 2008

Y1 - 2008

N2 - In the starfish, Asterias amurensis, three components in the jelly coat of eggs, namely acrosome reaction-inducing substance (ARIS), Co-ARIS and asterosap, act in concert on homologous spermatozoa to induce the acrosome reaction (AR). Molecular recognition between the sperm surface molecules and the egg jelly molecules must underlie signal transduction events triggering the AR. Asterosap is a sperm-activating molecule, which stimulates rapid synthesis of intracellular cGMP, pH and Ca2+. This transient elevation of Ca2+ level is caused by a K+-dependent Na+/Ca2+ exchanger, and the increase of intracellular pH is sufficient for ARIS to induce the AR. The concerted action of ARIS and asterosap could induce elevate intracellular cAMP levels in starfish sperm and the sustained increase in [Ca2+], which is essential for the AR. The signaling pathway induced by these factors seems to be synergistically regulated to trigger the AR in starfish sperm.

AB - In the starfish, Asterias amurensis, three components in the jelly coat of eggs, namely acrosome reaction-inducing substance (ARIS), Co-ARIS and asterosap, act in concert on homologous spermatozoa to induce the acrosome reaction (AR). Molecular recognition between the sperm surface molecules and the egg jelly molecules must underlie signal transduction events triggering the AR. Asterosap is a sperm-activating molecule, which stimulates rapid synthesis of intracellular cGMP, pH and Ca2+. This transient elevation of Ca2+ level is caused by a K+-dependent Na+/Ca2+ exchanger, and the increase of intracellular pH is sufficient for ARIS to induce the AR. The concerted action of ARIS and asterosap could induce elevate intracellular cAMP levels in starfish sperm and the sustained increase in [Ca2+], which is essential for the AR. The signaling pathway induced by these factors seems to be synergistically regulated to trigger the AR in starfish sperm.

KW - Cyclic nucleotides

KW - Invertebrate fertilization

KW - Ion channel

KW - Signal transduction

KW - Spermatozoa

UR - http://www.scopus.com/inward/record.url?scp=54249118709&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=54249118709&partnerID=8YFLogxK

U2 - 10.1387/ijdb.072511mm

DO - 10.1387/ijdb.072511mm

M3 - Article

VL - 52

SP - 523

EP - 526

JO - International Journal of Developmental Biology

JF - International Journal of Developmental Biology

SN - 0214-6282

IS - 5-6

ER -