Regulation of TLR signaling and inflammation by SOCS family proteins

Akihiko Yoshimura, Hiroyuki Mori Masanobu Ohishi, Daisuke Aki, Toshikatsu Hanada

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. These cytokines exert their biological functions through Janus tyrosine kinases and signal transducer and activator of transcription factors. The cytokine-inducible Src homology 2 protein (CIS) and suppressors of cytokine signaling (SOCS) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine responses, including those that regulate the inflammatory systems. In this short review, we focused on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in Toll-like receptor signal regulation and inflammatory diseases.

Original languageEnglish
Pages (from-to)422-427
Number of pages6
JournalJournal of Leukocyte Biology
Volume75
Issue number3
DOIs
Publication statusPublished - 2004 Mar
Externally publishedYes

Fingerprint

Suppressor of Cytokine Signaling Proteins
Cytokines
Inflammation
Janus Kinases
Toll-Like Receptors
Interleukins
Transducers
Protein-Tyrosine Kinases
Interferons
Immune System
Transcription Factors
Proteins

Keywords

  • Cytokine
  • Endotoxin
  • Inflammatory bowel disease
  • NF-κB
  • Rheumatoid antithesis
  • STAT
  • Toll-like receptor
  • Tyrosine kinase

ASJC Scopus subject areas

  • Cell Biology

Cite this

Regulation of TLR signaling and inflammation by SOCS family proteins. / Yoshimura, Akihiko; Ohishi, Hiroyuki Mori Masanobu; Aki, Daisuke; Hanada, Toshikatsu.

In: Journal of Leukocyte Biology, Vol. 75, No. 3, 03.2004, p. 422-427.

Research output: Contribution to journalArticle

Yoshimura, Akihiko ; Ohishi, Hiroyuki Mori Masanobu ; Aki, Daisuke ; Hanada, Toshikatsu. / Regulation of TLR signaling and inflammation by SOCS family proteins. In: Journal of Leukocyte Biology. 2004 ; Vol. 75, No. 3. pp. 422-427.
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