Regulatory mechanisms of immune responses to intestinal bacteria

K. Honda, K. Takeda

Research output: Contribution to journalReview article

71 Citations (Scopus)

Abstract

The intestinal mucosa allows the residence of trillions of bacteria with which it interacts dynamically. To establish and maintain a mutually beneficial relationship, the mucosal immune system must enforce tolerance toward the vast non-pathogenic microbiota while simultaneously remaining reactive to potentially pathogenic microbes; the disruption of this delicate balance results in inflammatory bowel diseases. In this review, we describe advances in our understanding of regulatory mechanisms of the innate immune system and how these shape adaptive immune systems during steady-state and inflammatory processes in the intestinal mucosa.

Original languageEnglish
Pages (from-to)187-196
Number of pages10
JournalMucosal Immunology
Volume2
Issue number3
DOIs
Publication statusPublished - 2009 May 7
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this