Relation between climacteric symptoms and ovarian hypofunction in middle-aged and older Japanese women

Michiko Kasuga, Kazuya Makita, Ken Ishitani, Kiyoshi Takamatsu, Kenji Watanabe, Gregory A. Plotnikoff, Fumi Horiguchi, Shiro Nozawa

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective: To gain insight into the characteristics and current status of climacteric symptoms reported by middle-aged and older women in Japan, we surveyed women presenting at our menopause clinic. Design: The participants included 1,069 women, ranging in age from 40 to less than 60 years (mean age, 50.2 y). Climacteric (indefinite) symptoms were objectively assessed with the use of the Keio questionnaire, which grades the severity of 40 types of symptoms classified into 20 subgroups. The total scores obtained for the 40 symptoms were used to calculate symptom prevalence and severity. To evaluate ovarian function, concentrations of estradiol and follicle-stimulating hormone (FSH) in sera were measured. Results: The most frequent symptom was general fatigue, reported by 88.2% of the women. Shoulder stiffness was the symptom rated to be severe by the highest percentage of women (38.1%). The prevalence and severity of hot flushes (and sweats) were slightly higher in perimenopausal and early postmenopausal women than in premenopausal and late postmenopausal women. The prevalence and severity of hot flushes and sweats were higher in women with estradiol < 25 pg/mL and FSH > 40 mIU/mL than in those with estradiol ≥ 25 pg/mL and FSH ≤ 40 mIU/mL. Conclusion: General fatigue and shoulder stiffness, symptoms with low hormone dependence, are the two most frequent climacteric symptoms in our clinic. Hot flushes and sweats, symptoms with high hormone dependence, are also common symptoms.

Original languageEnglish
Pages (from-to)631-638
Number of pages8
JournalMenopause
Volume11
Issue number6 I
DOIs
Publication statusPublished - 2004

Fingerprint

Sweat
Estradiol
Follicle Stimulating Hormone
Fatigue
Hormones
Menopause
Japan
Serum

Keywords

  • Climacteric symptoms
  • Indefinite complaints
  • Menopause
  • Menopause clinic
  • Ovarian function

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Kasuga, M., Makita, K., Ishitani, K., Takamatsu, K., Watanabe, K., Plotnikoff, G. A., ... Nozawa, S. (2004). Relation between climacteric symptoms and ovarian hypofunction in middle-aged and older Japanese women. Menopause, 11(6 I), 631-638. https://doi.org/10.1097/01.GME.0000119984.87302.30

Relation between climacteric symptoms and ovarian hypofunction in middle-aged and older Japanese women. / Kasuga, Michiko; Makita, Kazuya; Ishitani, Ken; Takamatsu, Kiyoshi; Watanabe, Kenji; Plotnikoff, Gregory A.; Horiguchi, Fumi; Nozawa, Shiro.

In: Menopause, Vol. 11, No. 6 I, 2004, p. 631-638.

Research output: Contribution to journalArticle

Kasuga, M, Makita, K, Ishitani, K, Takamatsu, K, Watanabe, K, Plotnikoff, GA, Horiguchi, F & Nozawa, S 2004, 'Relation between climacteric symptoms and ovarian hypofunction in middle-aged and older Japanese women', Menopause, vol. 11, no. 6 I, pp. 631-638. https://doi.org/10.1097/01.GME.0000119984.87302.30
Kasuga, Michiko ; Makita, Kazuya ; Ishitani, Ken ; Takamatsu, Kiyoshi ; Watanabe, Kenji ; Plotnikoff, Gregory A. ; Horiguchi, Fumi ; Nozawa, Shiro. / Relation between climacteric symptoms and ovarian hypofunction in middle-aged and older Japanese women. In: Menopause. 2004 ; Vol. 11, No. 6 I. pp. 631-638.
@article{a4c2e488026544619a986eb7051180c0,
title = "Relation between climacteric symptoms and ovarian hypofunction in middle-aged and older Japanese women",
abstract = "Objective: To gain insight into the characteristics and current status of climacteric symptoms reported by middle-aged and older women in Japan, we surveyed women presenting at our menopause clinic. Design: The participants included 1,069 women, ranging in age from 40 to less than 60 years (mean age, 50.2 y). Climacteric (indefinite) symptoms were objectively assessed with the use of the Keio questionnaire, which grades the severity of 40 types of symptoms classified into 20 subgroups. The total scores obtained for the 40 symptoms were used to calculate symptom prevalence and severity. To evaluate ovarian function, concentrations of estradiol and follicle-stimulating hormone (FSH) in sera were measured. Results: The most frequent symptom was general fatigue, reported by 88.2{\%} of the women. Shoulder stiffness was the symptom rated to be severe by the highest percentage of women (38.1{\%}). The prevalence and severity of hot flushes (and sweats) were slightly higher in perimenopausal and early postmenopausal women than in premenopausal and late postmenopausal women. The prevalence and severity of hot flushes and sweats were higher in women with estradiol < 25 pg/mL and FSH > 40 mIU/mL than in those with estradiol ≥ 25 pg/mL and FSH ≤ 40 mIU/mL. Conclusion: General fatigue and shoulder stiffness, symptoms with low hormone dependence, are the two most frequent climacteric symptoms in our clinic. Hot flushes and sweats, symptoms with high hormone dependence, are also common symptoms.",
keywords = "Climacteric symptoms, Indefinite complaints, Menopause, Menopause clinic, Ovarian function",
author = "Michiko Kasuga and Kazuya Makita and Ken Ishitani and Kiyoshi Takamatsu and Kenji Watanabe and Plotnikoff, {Gregory A.} and Fumi Horiguchi and Shiro Nozawa",
year = "2004",
doi = "10.1097/01.GME.0000119984.87302.30",
language = "English",
volume = "11",
pages = "631--638",
journal = "Menopause",
issn = "1072-3714",
publisher = "Lippincott Williams and Wilkins",
number = "6 I",

}

TY - JOUR

T1 - Relation between climacteric symptoms and ovarian hypofunction in middle-aged and older Japanese women

AU - Kasuga, Michiko

AU - Makita, Kazuya

AU - Ishitani, Ken

AU - Takamatsu, Kiyoshi

AU - Watanabe, Kenji

AU - Plotnikoff, Gregory A.

AU - Horiguchi, Fumi

AU - Nozawa, Shiro

PY - 2004

Y1 - 2004

N2 - Objective: To gain insight into the characteristics and current status of climacteric symptoms reported by middle-aged and older women in Japan, we surveyed women presenting at our menopause clinic. Design: The participants included 1,069 women, ranging in age from 40 to less than 60 years (mean age, 50.2 y). Climacteric (indefinite) symptoms were objectively assessed with the use of the Keio questionnaire, which grades the severity of 40 types of symptoms classified into 20 subgroups. The total scores obtained for the 40 symptoms were used to calculate symptom prevalence and severity. To evaluate ovarian function, concentrations of estradiol and follicle-stimulating hormone (FSH) in sera were measured. Results: The most frequent symptom was general fatigue, reported by 88.2% of the women. Shoulder stiffness was the symptom rated to be severe by the highest percentage of women (38.1%). The prevalence and severity of hot flushes (and sweats) were slightly higher in perimenopausal and early postmenopausal women than in premenopausal and late postmenopausal women. The prevalence and severity of hot flushes and sweats were higher in women with estradiol < 25 pg/mL and FSH > 40 mIU/mL than in those with estradiol ≥ 25 pg/mL and FSH ≤ 40 mIU/mL. Conclusion: General fatigue and shoulder stiffness, symptoms with low hormone dependence, are the two most frequent climacteric symptoms in our clinic. Hot flushes and sweats, symptoms with high hormone dependence, are also common symptoms.

AB - Objective: To gain insight into the characteristics and current status of climacteric symptoms reported by middle-aged and older women in Japan, we surveyed women presenting at our menopause clinic. Design: The participants included 1,069 women, ranging in age from 40 to less than 60 years (mean age, 50.2 y). Climacteric (indefinite) symptoms were objectively assessed with the use of the Keio questionnaire, which grades the severity of 40 types of symptoms classified into 20 subgroups. The total scores obtained for the 40 symptoms were used to calculate symptom prevalence and severity. To evaluate ovarian function, concentrations of estradiol and follicle-stimulating hormone (FSH) in sera were measured. Results: The most frequent symptom was general fatigue, reported by 88.2% of the women. Shoulder stiffness was the symptom rated to be severe by the highest percentage of women (38.1%). The prevalence and severity of hot flushes (and sweats) were slightly higher in perimenopausal and early postmenopausal women than in premenopausal and late postmenopausal women. The prevalence and severity of hot flushes and sweats were higher in women with estradiol < 25 pg/mL and FSH > 40 mIU/mL than in those with estradiol ≥ 25 pg/mL and FSH ≤ 40 mIU/mL. Conclusion: General fatigue and shoulder stiffness, symptoms with low hormone dependence, are the two most frequent climacteric symptoms in our clinic. Hot flushes and sweats, symptoms with high hormone dependence, are also common symptoms.

KW - Climacteric symptoms

KW - Indefinite complaints

KW - Menopause

KW - Menopause clinic

KW - Ovarian function

UR - http://www.scopus.com/inward/record.url?scp=14844341620&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=14844341620&partnerID=8YFLogxK

U2 - 10.1097/01.GME.0000119984.87302.30

DO - 10.1097/01.GME.0000119984.87302.30

M3 - Article

C2 - 15545791

AN - SCOPUS:14844341620

VL - 11

SP - 631

EP - 638

JO - Menopause

JF - Menopause

SN - 1072-3714

IS - 6 I

ER -