Relation between localization of gastric mucosal lesions and microvascular disturbance

Hiroshi Nagata, Tetsuo Morishita, Haruyuki Minamitani, Masayuki Suzuki, Makoto Suematsu, Soichrio Miura, Shigenari Houzawa, Masaya Oda, Masaharu Tsuchiya

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Acute gastric mucosal lesions in the rats were produced by intermittent electrical stimuli to a main trunk of the left gastric artery (LGA), right gastroepiploic artery (RGEA) or a posterior branch of the left gastric artery (PLGA). The image processing analysis was applied to determine the relation between distribution of the lesions and perfusion area of the supplying artery to which electrical stimuli were given. Electrical stimuli of 50Hz, 5msec, 100μA was applied to the artery for 30 sc three times with 10sec interval. A series of these stimuli was repeated three times. The mucosal blood flow measured with the laser doppler method in each perfusion area was reduced to less than 35% of the control value during the electrical stimuli for 30sec. After the repeated electrical stimuli to LGA, 85.8 and 95.4% of the mucosal lesions were found in the mean and maximum perfusion area of LGA, respectively. Electrical stimuli to PLGA caused 84.5% and 95.3 of the lesions in the mean and maximum area of PLGA, respectively. Stimuli to RGEA caused 53.4% and 74.1% of the lesions in the mean and maximum perfusion area of RGEA. In the antrum, electrical stimuli to LGA, PLGA or RGEA produced 0%, 5.4% or 5.0% of the mucosal lesions. It is concluded that the corpus mucosal lesions induced by regional ischemia are distributed in the ischemic area.

Original languageEnglish
Pages (from-to)1357-1363
Number of pages7
JournalNippon Shokakibyo Gakkai Zasshi
Volume87
Issue number6
DOIs
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint Dive into the research topics of 'Relation between localization of gastric mucosal lesions and microvascular disturbance'. Together they form a unique fingerprint.

  • Cite this

    Nagata, H., Morishita, T., Minamitani, H., Suzuki, M., Suematsu, M., Miura, S., Houzawa, S., Oda, M., & Tsuchiya, M. (1990). Relation between localization of gastric mucosal lesions and microvascular disturbance. Nippon Shokakibyo Gakkai Zasshi, 87(6), 1357-1363. https://doi.org/10.11405/nisshoshi1964.87.1357