Relation between serum total cholesterol level and cardiovascular disease stratified by sex and age group

a pooled analysis of 65 594 individuals from 10 cohort studies in Japan.

Sin ya Nagasawa, Tomonori Okamura, Hiroyasu Iso, Akiko Tamakoshi, Michiko Yamada, Makoto Watanabe, Yoshitaka Murakami, Katsuyuki Miura, Hirotsugu Ueshima, for Cardiovascular Prevention from Observational Evidence for Cardiovascular Prevention from Observational, in Japan (EPOCH-JAPAN) Research Group Cohorts in Japan (EPOCH-JAPAN) Research Group

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The relation between serum total cholesterol (TC) and cardiovascular disease in women and in the elderly is unclear, especially in Asian populations. We examined this relation in the largest-scale pooled analysis of the Japanese population, the Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH-JAPAN) study. A total of 65 594 participants who were 40 to 89 years of age and did not have a past history of cardiovascular disease were examined. Cox proportional-hazards models were used to estimate hazard ratios for death from total stroke, cerebral infarction, intracranial cerebral hemorrhage, or coronary heart disease. The mean follow-up period was 10.1 years, with the number of deaths from total stroke, cerebral infarction, cerebral hemorrhage, and coronary heart disease being 875, 457, 212, and 374, respectively. The participants were divided into 2 age groups: middle-aged (40 to 69 years; mean age 55 years) and elderly (70 to 89 years; mean age 75 years). In men, the multivariate-adjusted hazard ratios for coronary heart disease in the highest TC category (≥6.21 mmol/L) compared with the lowest category (<4.14 mmol/L) were 2.52 (95% confidence interval: 1.15-5.07) in middle-aged participants and 2.77 (1.09-7.03) in elderly participants. In women, the hazard ratios of the highest TC category (≥6.72 mmol/L) compared with the lowest category (<4.66 mmol/L) were 3.20 (1.44-7.09) in middle-aged participants and 1.02 (0.42-2.49) in elderly participants. TC levels were not associated with cerebral infarction in any age or sex group and were associated negatively with total stroke and cerebral hemorrhage. High serum TC levels are associated with coronary heart disease in middle-aged Japanese men and women, but evidence in elderly Japanese individuals is still limited.

Original languageEnglish
JournalJournal of the American Heart Association
Volume1
Issue number5
DOIs
Publication statusPublished - 2012 Oct
Externally publishedYes

Fingerprint

Japan
Cohort Studies
Cardiovascular Diseases
Age Groups
Cholesterol
Coronary Disease
Cerebral Infarction
Cerebral Hemorrhage
Serum
Stroke
Intracranial Hemorrhages
Proportional Hazards Models
Population
Confidence Intervals

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Relation between serum total cholesterol level and cardiovascular disease stratified by sex and age group : a pooled analysis of 65 594 individuals from 10 cohort studies in Japan. / Nagasawa, Sin ya; Okamura, Tomonori; Iso, Hiroyasu; Tamakoshi, Akiko; Yamada, Michiko; Watanabe, Makoto; Murakami, Yoshitaka; Miura, Katsuyuki; Ueshima, Hirotsugu; Evidence for Cardiovascular Prevention from Observational, for Cardiovascular Prevention from Observational; Cohorts in Japan (EPOCH-JAPAN) Research Group, in Japan (EPOCH-JAPAN) Research Group.

In: Journal of the American Heart Association, Vol. 1, No. 5, 10.2012.

Research output: Contribution to journalArticle

Nagasawa, SY, Okamura, T, Iso, H, Tamakoshi, A, Yamada, M, Watanabe, M, Murakami, Y, Miura, K, Ueshima, H, Evidence for Cardiovascular Prevention from Observational, FCPFO & Cohorts in Japan (EPOCH-JAPAN) Research Group, IJEPOCH-JAPANRG 2012, 'Relation between serum total cholesterol level and cardiovascular disease stratified by sex and age group: a pooled analysis of 65 594 individuals from 10 cohort studies in Japan.', Journal of the American Heart Association, vol. 1, no. 5. https://doi.org/10.1161/JAHA.112.001974
Nagasawa, Sin ya ; Okamura, Tomonori ; Iso, Hiroyasu ; Tamakoshi, Akiko ; Yamada, Michiko ; Watanabe, Makoto ; Murakami, Yoshitaka ; Miura, Katsuyuki ; Ueshima, Hirotsugu ; Evidence for Cardiovascular Prevention from Observational, for Cardiovascular Prevention from Observational ; Cohorts in Japan (EPOCH-JAPAN) Research Group, in Japan (EPOCH-JAPAN) Research Group. / Relation between serum total cholesterol level and cardiovascular disease stratified by sex and age group : a pooled analysis of 65 594 individuals from 10 cohort studies in Japan. In: Journal of the American Heart Association. 2012 ; Vol. 1, No. 5.
@article{ad44bc376188482ba128482e644bdfd7,
title = "Relation between serum total cholesterol level and cardiovascular disease stratified by sex and age group: a pooled analysis of 65 594 individuals from 10 cohort studies in Japan.",
abstract = "The relation between serum total cholesterol (TC) and cardiovascular disease in women and in the elderly is unclear, especially in Asian populations. We examined this relation in the largest-scale pooled analysis of the Japanese population, the Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH-JAPAN) study. A total of 65 594 participants who were 40 to 89 years of age and did not have a past history of cardiovascular disease were examined. Cox proportional-hazards models were used to estimate hazard ratios for death from total stroke, cerebral infarction, intracranial cerebral hemorrhage, or coronary heart disease. The mean follow-up period was 10.1 years, with the number of deaths from total stroke, cerebral infarction, cerebral hemorrhage, and coronary heart disease being 875, 457, 212, and 374, respectively. The participants were divided into 2 age groups: middle-aged (40 to 69 years; mean age 55 years) and elderly (70 to 89 years; mean age 75 years). In men, the multivariate-adjusted hazard ratios for coronary heart disease in the highest TC category (≥6.21 mmol/L) compared with the lowest category (<4.14 mmol/L) were 2.52 (95{\%} confidence interval: 1.15-5.07) in middle-aged participants and 2.77 (1.09-7.03) in elderly participants. In women, the hazard ratios of the highest TC category (≥6.72 mmol/L) compared with the lowest category (<4.66 mmol/L) were 3.20 (1.44-7.09) in middle-aged participants and 1.02 (0.42-2.49) in elderly participants. TC levels were not associated with cerebral infarction in any age or sex group and were associated negatively with total stroke and cerebral hemorrhage. High serum TC levels are associated with coronary heart disease in middle-aged Japanese men and women, but evidence in elderly Japanese individuals is still limited.",
author = "Nagasawa, {Sin ya} and Tomonori Okamura and Hiroyasu Iso and Akiko Tamakoshi and Michiko Yamada and Makoto Watanabe and Yoshitaka Murakami and Katsuyuki Miura and Hirotsugu Ueshima and {Evidence for Cardiovascular Prevention from Observational}, {for Cardiovascular Prevention from Observational} and {Cohorts in Japan (EPOCH-JAPAN) Research Group}, {in Japan (EPOCH-JAPAN) Research Group}",
year = "2012",
month = "10",
doi = "10.1161/JAHA.112.001974",
language = "English",
volume = "1",
journal = "Journal of the American Heart Association",
issn = "2047-9980",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Relation between serum total cholesterol level and cardiovascular disease stratified by sex and age group

T2 - a pooled analysis of 65 594 individuals from 10 cohort studies in Japan.

AU - Nagasawa, Sin ya

AU - Okamura, Tomonori

AU - Iso, Hiroyasu

AU - Tamakoshi, Akiko

AU - Yamada, Michiko

AU - Watanabe, Makoto

AU - Murakami, Yoshitaka

AU - Miura, Katsuyuki

AU - Ueshima, Hirotsugu

AU - Evidence for Cardiovascular Prevention from Observational, for Cardiovascular Prevention from Observational

AU - Cohorts in Japan (EPOCH-JAPAN) Research Group, in Japan (EPOCH-JAPAN) Research Group

PY - 2012/10

Y1 - 2012/10

N2 - The relation between serum total cholesterol (TC) and cardiovascular disease in women and in the elderly is unclear, especially in Asian populations. We examined this relation in the largest-scale pooled analysis of the Japanese population, the Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH-JAPAN) study. A total of 65 594 participants who were 40 to 89 years of age and did not have a past history of cardiovascular disease were examined. Cox proportional-hazards models were used to estimate hazard ratios for death from total stroke, cerebral infarction, intracranial cerebral hemorrhage, or coronary heart disease. The mean follow-up period was 10.1 years, with the number of deaths from total stroke, cerebral infarction, cerebral hemorrhage, and coronary heart disease being 875, 457, 212, and 374, respectively. The participants were divided into 2 age groups: middle-aged (40 to 69 years; mean age 55 years) and elderly (70 to 89 years; mean age 75 years). In men, the multivariate-adjusted hazard ratios for coronary heart disease in the highest TC category (≥6.21 mmol/L) compared with the lowest category (<4.14 mmol/L) were 2.52 (95% confidence interval: 1.15-5.07) in middle-aged participants and 2.77 (1.09-7.03) in elderly participants. In women, the hazard ratios of the highest TC category (≥6.72 mmol/L) compared with the lowest category (<4.66 mmol/L) were 3.20 (1.44-7.09) in middle-aged participants and 1.02 (0.42-2.49) in elderly participants. TC levels were not associated with cerebral infarction in any age or sex group and were associated negatively with total stroke and cerebral hemorrhage. High serum TC levels are associated with coronary heart disease in middle-aged Japanese men and women, but evidence in elderly Japanese individuals is still limited.

AB - The relation between serum total cholesterol (TC) and cardiovascular disease in women and in the elderly is unclear, especially in Asian populations. We examined this relation in the largest-scale pooled analysis of the Japanese population, the Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH-JAPAN) study. A total of 65 594 participants who were 40 to 89 years of age and did not have a past history of cardiovascular disease were examined. Cox proportional-hazards models were used to estimate hazard ratios for death from total stroke, cerebral infarction, intracranial cerebral hemorrhage, or coronary heart disease. The mean follow-up period was 10.1 years, with the number of deaths from total stroke, cerebral infarction, cerebral hemorrhage, and coronary heart disease being 875, 457, 212, and 374, respectively. The participants were divided into 2 age groups: middle-aged (40 to 69 years; mean age 55 years) and elderly (70 to 89 years; mean age 75 years). In men, the multivariate-adjusted hazard ratios for coronary heart disease in the highest TC category (≥6.21 mmol/L) compared with the lowest category (<4.14 mmol/L) were 2.52 (95% confidence interval: 1.15-5.07) in middle-aged participants and 2.77 (1.09-7.03) in elderly participants. In women, the hazard ratios of the highest TC category (≥6.72 mmol/L) compared with the lowest category (<4.66 mmol/L) were 3.20 (1.44-7.09) in middle-aged participants and 1.02 (0.42-2.49) in elderly participants. TC levels were not associated with cerebral infarction in any age or sex group and were associated negatively with total stroke and cerebral hemorrhage. High serum TC levels are associated with coronary heart disease in middle-aged Japanese men and women, but evidence in elderly Japanese individuals is still limited.

UR - http://www.scopus.com/inward/record.url?scp=84879409207&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879409207&partnerID=8YFLogxK

U2 - 10.1161/JAHA.112.001974

DO - 10.1161/JAHA.112.001974

M3 - Article

VL - 1

JO - Journal of the American Heart Association

JF - Journal of the American Heart Association

SN - 2047-9980

IS - 5

ER -