Relation between structures and functions of gel-like nanoparticles with thermo-responsitiveness

Masatoshi Narikawa, Keiji Fujimoto

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

To design nanoparticles of a stimuli-sensitive gel, we prepared a copolymer having both thermo-responsitiveness and reactivity. The copolymers were obtained by solution polymerization with N-isopropylacrylamide and N-methacryloxysuccinimide, and they were allowed to react with cystamine and were reduced to introduce sulfhydryl groups. The obtained polymers were precipitated to form nanoparticles by raising temperature, and then nanoparticles were cross-linked with disulfide bonds. The nanoparticle could be disrupted by the breakage of disulfide bonds when the reducing reagents were added. This behavior was related to the molecular size of reducing agents. Macromolecules like proteins could be incorporated into the particles to a higher degree than small molecules. This is because nanoparticles were gel-like and their cross-linking density was relatively low.

Original languageEnglish
Title of host publicationPolymer Preprints, Japan
Pages1800
Number of pages1
Volume54
Edition1
Publication statusPublished - 2005
Event54th SPSJ Annual Meeting 2005 - Yokohama, Japan
Duration: 2005 May 252005 May 27

Other

Other54th SPSJ Annual Meeting 2005
CountryJapan
CityYokohama
Period05/5/2505/5/27

Fingerprint

Gels
Nanoparticles
Copolymers
Reducing agents
Macromolecules
Polymerization
Proteins
Molecules
Polymers
Temperature

Keywords

  • Disulfide bonding
  • Gel particles
  • Nanoparticles

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Narikawa, M., & Fujimoto, K. (2005). Relation between structures and functions of gel-like nanoparticles with thermo-responsitiveness. In Polymer Preprints, Japan (1 ed., Vol. 54, pp. 1800)

Relation between structures and functions of gel-like nanoparticles with thermo-responsitiveness. / Narikawa, Masatoshi; Fujimoto, Keiji.

Polymer Preprints, Japan. Vol. 54 1. ed. 2005. p. 1800.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Narikawa, M & Fujimoto, K 2005, Relation between structures and functions of gel-like nanoparticles with thermo-responsitiveness. in Polymer Preprints, Japan. 1 edn, vol. 54, pp. 1800, 54th SPSJ Annual Meeting 2005, Yokohama, Japan, 05/5/25.
Narikawa, Masatoshi ; Fujimoto, Keiji. / Relation between structures and functions of gel-like nanoparticles with thermo-responsitiveness. Polymer Preprints, Japan. Vol. 54 1. ed. 2005. pp. 1800
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