Relationship between fasting and 2-hour postprandial plasma glucose levels and vascular complications in patients with type 2 diabetes mellitus

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Abstract

To investigate the relationship between fasting and 2-h postprandial plasma glucose concentrations and vascular complications in type 2 diabetes. METHODS: Consecutive patients with type 2 diabetes admitted for blood glucose control were grouped according to their fasting and 2-h postprandial plasma glucose levels. Frequency and severity of diabetic retinopathy and nephropathy, number of carotid artery plaques, coefficient of variation of R-R intervals (CVRR), brachial-ankle pulse wave velocity (baPWV), intima-media thickness, brain natriuretic peptide level, ankle-brachial index, and high-sensitivity C-reactive protein levels were compared. RESULTS: In the 206 patients studied, mean ± SD age, glycosylated haemoglobin and duration of diabetes were 63.4 ± 13.7 years, 9.8 ± 1.8% and 13.4 ± 8.9 years, respectively. Patients with high fasting plasma glucose levels had a higher frequency of proliferative retinopathy than those with low fasting levels. Patients with medium or high 2-h postprandial plasma glucose levels had higher baPWV and lower CVRR, respectively, than those with low 2-h levels. There was an inverse correlation between baPWV and CVRR. CONCLUSION: Elevated fasting and postprandial plasma glucose levels are risk factors for vascular complications in type 2 diabetes mellitus.

Original languageEnglish
Pages (from-to)1295-1303
Number of pages9
JournalJournal of International Medical Research
Volume40
Issue number4
DOIs
Publication statusPublished - 2012 Jan 1

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Medical problems
Type 2 Diabetes Mellitus
Blood Vessels
Fasting
Pulse Wave Analysis
Plasmas
Glucose
Ankle
Arm
Ankle Brachial Index
Brain Natriuretic Peptide
Carotid Stenosis
Glycosylated Hemoglobin A
Diabetic Nephropathies
Diabetic Retinopathy
C-Reactive Protein
Blood Glucose

Keywords

  • Brachial-ankle pulse wave velocity
  • Coefficient of variation of r-r intervals
  • Diabetic retinopathy
  • Macroangiopathy
  • Microangiopathy
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

Cite this

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abstract = "To investigate the relationship between fasting and 2-h postprandial plasma glucose concentrations and vascular complications in type 2 diabetes. METHODS: Consecutive patients with type 2 diabetes admitted for blood glucose control were grouped according to their fasting and 2-h postprandial plasma glucose levels. Frequency and severity of diabetic retinopathy and nephropathy, number of carotid artery plaques, coefficient of variation of R-R intervals (CVRR), brachial-ankle pulse wave velocity (baPWV), intima-media thickness, brain natriuretic peptide level, ankle-brachial index, and high-sensitivity C-reactive protein levels were compared. RESULTS: In the 206 patients studied, mean ± SD age, glycosylated haemoglobin and duration of diabetes were 63.4 ± 13.7 years, 9.8 ± 1.8{\%} and 13.4 ± 8.9 years, respectively. Patients with high fasting plasma glucose levels had a higher frequency of proliferative retinopathy than those with low fasting levels. Patients with medium or high 2-h postprandial plasma glucose levels had higher baPWV and lower CVRR, respectively, than those with low 2-h levels. There was an inverse correlation between baPWV and CVRR. CONCLUSION: Elevated fasting and postprandial plasma glucose levels are risk factors for vascular complications in type 2 diabetes mellitus.",
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AB - To investigate the relationship between fasting and 2-h postprandial plasma glucose concentrations and vascular complications in type 2 diabetes. METHODS: Consecutive patients with type 2 diabetes admitted for blood glucose control were grouped according to their fasting and 2-h postprandial plasma glucose levels. Frequency and severity of diabetic retinopathy and nephropathy, number of carotid artery plaques, coefficient of variation of R-R intervals (CVRR), brachial-ankle pulse wave velocity (baPWV), intima-media thickness, brain natriuretic peptide level, ankle-brachial index, and high-sensitivity C-reactive protein levels were compared. RESULTS: In the 206 patients studied, mean ± SD age, glycosylated haemoglobin and duration of diabetes were 63.4 ± 13.7 years, 9.8 ± 1.8% and 13.4 ± 8.9 years, respectively. Patients with high fasting plasma glucose levels had a higher frequency of proliferative retinopathy than those with low fasting levels. Patients with medium or high 2-h postprandial plasma glucose levels had higher baPWV and lower CVRR, respectively, than those with low 2-h levels. There was an inverse correlation between baPWV and CVRR. CONCLUSION: Elevated fasting and postprandial plasma glucose levels are risk factors for vascular complications in type 2 diabetes mellitus.

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