Relationship between fractional pancreatic beta cell area and fasting plasma glucose concentration in monkeys

Y. Saisho, A. E. Butler, E. Manesso, R. Galasso, L. Zhang, T. Gurlo, G. M. Toffolo, C. Cobelli, K. Kavanagh, J. D. Wagner, P. C. Butler

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19 Citations (Scopus)

Abstract

Aims/hypothesis: We sought to establish the relationship between fasting plasma glucose concentrations and pancreatic fractional beta cell area in adult cynomolgus monkeys (Macaca fascicularis). Methods: Fasting plasma glucose and pancreatic fractional beta cell area were measured in 18 control and 17 streptozotocin-treated adult primates (17.0±1.2 vs 15.4±1.2 years old). Results: Fasting plasma glucose was increased (12.0±2.0 vs 3.4±0.1 mmol/l, p<0.01) and fractional beta cell area was decreased (0.62±0.13% vs 2.49±0.35%, p<0.01) in streptozotocin-treated monkeys. The relationship between fasting plasma glucose and pancreatic fractional beta cell area was described by a wide range of beta cell areas in controls. In streptozotocin-treated monkeys there was an inflection of fasting blood glucose at ∼ 50% of the mean beta cell area in controls with a steep increase in blood glucose for each further decrement in beta cell area. Conclusions/interpretation: In adult non-human primates a decrement in fractional beta cell area of ∼ 50% or more leads to loss of glycaemic control.

Original languageEnglish
Pages (from-to)111-114
Number of pages4
JournalDiabetologia
Volume53
Issue number1
DOIs
Publication statusPublished - 2010 Jan 1

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Keywords

  • Beta cell mass
  • Cynomolgus monkey
  • Streptozotocin
  • Type 1 diabetes
  • Type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Saisho, Y., Butler, A. E., Manesso, E., Galasso, R., Zhang, L., Gurlo, T., Toffolo, G. M., Cobelli, C., Kavanagh, K., Wagner, J. D., & Butler, P. C. (2010). Relationship between fractional pancreatic beta cell area and fasting plasma glucose concentration in monkeys. Diabetologia, 53(1), 111-114. https://doi.org/10.1007/s00125-009-1552-z