Relationship Between Increased Expression of the Axl/Gas6 Signal Cascade and Prognosis of Patients with Upper Tract Urothelial Carcinoma

Seiya Hattori, Eiji Kikuchi, Takeo Kosaka, Yasumasa Miyazaki, Nobuyuki Tanaka, Akira Miyajima, Shuji Mikami, Mototsugu Oya

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Purpose: Axl, which is in the TAM family of receptor tyrosine kinases, and its ligand, growth arrest-specific gene 6 (Gas6), have been associated with worse prognoses after the surgical treatment of some types of cancers. We herein investigated the biological significance of the protein expression of Axl and Gas6 on the outcomes of patients with upper tract urothelial carcinoma (UTUC). Methods: The protein expression of Axl and Gas6 was evaluated by immunohistochemistry, and their relationships with clinicopathological features were investigated in surgical specimens obtained from 161 patients who had been surgically treated for UTUC. Results: Axl labeling was strong in 67 of 161 (42 %) cases, while Gas6 labeling was strong in 72 of 161 (45 %) cases. The strong expression of Axl correlated with that of Gas6. A high pathological stage (p = 0.009), strong expression of Gas6 (p = 0.038), and strong expression of Axl (p = 0.016) were independent factors for predicting worse cancer-specific survival (CSS). In a subgroup analysis of patients with pT 

Original languageEnglish
Pages (from-to)663-670
Number of pages8
JournalAnnals of Surgical Oncology
Volume23
Issue number2
DOIs
Publication statusPublished - 2016 Feb 1

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Carcinoma
Growth
Genes
Receptor Protein-Tyrosine Kinases
Neoplasms
Proteins
Immunohistochemistry
Ligands
Survival
Therapeutics

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Relationship Between Increased Expression of the Axl/Gas6 Signal Cascade and Prognosis of Patients with Upper Tract Urothelial Carcinoma. / Hattori, Seiya; Kikuchi, Eiji; Kosaka, Takeo; Miyazaki, Yasumasa; Tanaka, Nobuyuki; Miyajima, Akira; Mikami, Shuji; Oya, Mototsugu.

In: Annals of Surgical Oncology, Vol. 23, No. 2, 01.02.2016, p. 663-670.

Research output: Contribution to journalArticle

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AU - Hattori, Seiya

AU - Kikuchi, Eiji

AU - Kosaka, Takeo

AU - Miyazaki, Yasumasa

AU - Tanaka, Nobuyuki

AU - Miyajima, Akira

AU - Mikami, Shuji

AU - Oya, Mototsugu

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AB - Purpose: Axl, which is in the TAM family of receptor tyrosine kinases, and its ligand, growth arrest-specific gene 6 (Gas6), have been associated with worse prognoses after the surgical treatment of some types of cancers. We herein investigated the biological significance of the protein expression of Axl and Gas6 on the outcomes of patients with upper tract urothelial carcinoma (UTUC). Methods: The protein expression of Axl and Gas6 was evaluated by immunohistochemistry, and their relationships with clinicopathological features were investigated in surgical specimens obtained from 161 patients who had been surgically treated for UTUC. Results: Axl labeling was strong in 67 of 161 (42 %) cases, while Gas6 labeling was strong in 72 of 161 (45 %) cases. The strong expression of Axl correlated with that of Gas6. A high pathological stage (p = 0.009), strong expression of Gas6 (p = 0.038), and strong expression of Axl (p = 0.016) were independent factors for predicting worse cancer-specific survival (CSS). In a subgroup analysis of patients with pT 

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