Relationship between metabolic syndrome and Trp64Arg polymorphism of the β3-adrenergic receptor gene in a general sample: The Shigaraki study

Shinji Tamaki, Yasuyuki Nakamura, Yasuharu Tabara, Tomonori Okamura, Yoshikuni Kita, Takashi Kadowaki, Yasuyuki Tsujita, Minoru Horie, Tetsuro Miki, Hirotsugu Ueshima

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

It has been reported that the β3-adrenergic receptor gene (ADRB3) is associated with abnormal metabolic risk factors. Therefore, we examined whether the Trp64Arg polymorphism of ADRB3 affects the occurrence of metabolic syndrome (MS). The participants were 2,395 subjects who underwent a medical examination in Shigaraki in Shiga, Japan. Among them, 1,416 subjects who gave informed consent for genetic analysis and were not receiving treatment for hypertension, diabetes, or hyperlipidemia were enrolled in this study. MS was diagnosed in 86 (16.0%) of 537 men, and 8 (0.9%) of 879 women. There was no significant relationship between ADRB3 polymorphism and the frequency of MS. Multiple logistic regression analysis including smoking, sex, and age as confounding factors showed no interaction between MS and ADRB3 polymorphism (odds ratio: 0.94; 95% confidence interval: 0.59-1.49; p=0.78). Subjects were also analyzed according to differences in the number of abnormal metabolic risk factors. However, there was no significant relationship between ADRB3 polymorphism and the number of such factors. In conclusion, in a general sample, the frequency of MS as 16.0% in men, and 0.9% in women. There was no relationship between ADRB3 polymorphism and MS.

Original languageEnglish
Pages (from-to)891-896
Number of pages6
JournalHypertension Research
Volume29
Issue number11
DOIs
Publication statusPublished - 2006 Nov
Externally publishedYes

Fingerprint

Adrenergic Receptors
Genes
Hyperlipidemias
Informed Consent
Japan
Logistic Models
Smoking
Odds Ratio
Regression Analysis
Confidence Intervals
Hypertension

Keywords

  • β3-adrenergic receptor gene
  • Hypertension
  • Metabolic syndrome
  • Trp64Arg polymorphism

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Relationship between metabolic syndrome and Trp64Arg polymorphism of the β3-adrenergic receptor gene in a general sample : The Shigaraki study. / Tamaki, Shinji; Nakamura, Yasuyuki; Tabara, Yasuharu; Okamura, Tomonori; Kita, Yoshikuni; Kadowaki, Takashi; Tsujita, Yasuyuki; Horie, Minoru; Miki, Tetsuro; Ueshima, Hirotsugu.

In: Hypertension Research, Vol. 29, No. 11, 11.2006, p. 891-896.

Research output: Contribution to journalArticle

Tamaki, S, Nakamura, Y, Tabara, Y, Okamura, T, Kita, Y, Kadowaki, T, Tsujita, Y, Horie, M, Miki, T & Ueshima, H 2006, 'Relationship between metabolic syndrome and Trp64Arg polymorphism of the β3-adrenergic receptor gene in a general sample: The Shigaraki study', Hypertension Research, vol. 29, no. 11, pp. 891-896. https://doi.org/10.1291/hypres.29.891
Tamaki, Shinji ; Nakamura, Yasuyuki ; Tabara, Yasuharu ; Okamura, Tomonori ; Kita, Yoshikuni ; Kadowaki, Takashi ; Tsujita, Yasuyuki ; Horie, Minoru ; Miki, Tetsuro ; Ueshima, Hirotsugu. / Relationship between metabolic syndrome and Trp64Arg polymorphism of the β3-adrenergic receptor gene in a general sample : The Shigaraki study. In: Hypertension Research. 2006 ; Vol. 29, No. 11. pp. 891-896.
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