Relationship between Methyl CpG binding protein 2 and JC viral proteins

Kenta Takahashi; Yasuko Orba; Taichi Kimura; Lei Wang; Shinji Kohsaka; Masumi Tsuda; Mishie Tanino; Hiroshi Nishihara; Kazuo Nagashima; Hirofumi Sawa; Shinya Tanaka

doi:10.7883/yoken.66.126

Relationship between Methyl CpG binding protein 2 and JC viral proteins

Kenta Takahashi, Yasuko Orba, Taichi Kimura, Lei Wang, Shinji Kohsaka, Masumi Tsuda, Mishie Tanino, Hiroshi Nishihara, Kazuo Nagashima, Hirofumi Sawa, Shinya Tanaka

Clinical and Translational Research Center

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

JC virus (JCV) is a causative agent of progressive multifocal leukoencephalopathy (PML). Methyl CpG binding protein 2 (MeCP2) is a transcriptional control nuclear protein that is abundantly expressed in neurons. We previously observed that the MeCP2 protein is expressed in JCV large T antigen (TAg)-expressing glial cells in PML brains. To investigate the relationship between MeCP2 and JCV TAg, we examined the promoter activity and mRNA and protein expression levels of MeCP2 in JCV TAg-expressing cells. We found that JCV TAg enhances the promoter activity of MeCP2, but does not enhance the mRNA and protein levels of MeCP2. These results suggest that post-transcriptional mechanisms may play a role in MeCP2 expression.

Original language	English
Pages (from-to)	126-132
Number of pages	7
Journal	Japanese Journal of Infectious Diseases
Volume	66
Issue number	2
DOIs	https://doi.org/10.7883/yoken.66.126
Publication status	Published - 2013

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

Access to Document

10.7883/yoken.66.126

Fingerprint Dive into the research topics of 'Relationship between Methyl CpG binding protein 2 and JC viral proteins'. Together they form a unique fingerprint.

Cite this

Relationship between Methyl CpG binding protein 2 and JC viral proteins. / Takahashi, Kenta; Orba, Yasuko; Kimura, Taichi; Wang, Lei; Kohsaka, Shinji; Tsuda, Masumi; Tanino, Mishie; Nishihara, Hiroshi; Nagashima, Kazuo; Sawa, Hirofumi; Tanaka, Shinya.

In: Japanese Journal of Infectious Diseases, Vol. 66, No. 2, 2013, p. 126-132.

Research output: Contribution to journal › Article › peer-review

@article{09ede7724b3845d786006bee79eee8b1,

title = "Relationship between Methyl CpG binding protein 2 and JC viral proteins",

abstract = "JC virus (JCV) is a causative agent of progressive multifocal leukoencephalopathy (PML). Methyl CpG binding protein 2 (MeCP2) is a transcriptional control nuclear protein that is abundantly expressed in neurons. We previously observed that the MeCP2 protein is expressed in JCV large T antigen (TAg)-expressing glial cells in PML brains. To investigate the relationship between MeCP2 and JCV TAg, we examined the promoter activity and mRNA and protein expression levels of MeCP2 in JCV TAg-expressing cells. We found that JCV TAg enhances the promoter activity of MeCP2, but does not enhance the mRNA and protein levels of MeCP2. These results suggest that post-transcriptional mechanisms may play a role in MeCP2 expression.",

author = "Kenta Takahashi and Yasuko Orba and Taichi Kimura and Lei Wang and Shinji Kohsaka and Masumi Tsuda and Mishie Tanino and Hiroshi Nishihara and Kazuo Nagashima and Hirofumi Sawa and Shinya Tanaka",

year = "2013",

doi = "10.7883/yoken.66.126",

language = "English",

volume = "66",

pages = "126--132",

journal = "Japanese Journal of Infectious Diseases",

issn = "1344-6304",

publisher = "National Institute of Health",

number = "2",

}

TY - JOUR

T1 - Relationship between Methyl CpG binding protein 2 and JC viral proteins

AU - Takahashi, Kenta

AU - Orba, Yasuko

AU - Kimura, Taichi

AU - Wang, Lei

AU - Kohsaka, Shinji

AU - Tsuda, Masumi

AU - Tanino, Mishie

AU - Nishihara, Hiroshi

AU - Nagashima, Kazuo

AU - Sawa, Hirofumi

AU - Tanaka, Shinya

PY - 2013

Y1 - 2013

N2 - JC virus (JCV) is a causative agent of progressive multifocal leukoencephalopathy (PML). Methyl CpG binding protein 2 (MeCP2) is a transcriptional control nuclear protein that is abundantly expressed in neurons. We previously observed that the MeCP2 protein is expressed in JCV large T antigen (TAg)-expressing glial cells in PML brains. To investigate the relationship between MeCP2 and JCV TAg, we examined the promoter activity and mRNA and protein expression levels of MeCP2 in JCV TAg-expressing cells. We found that JCV TAg enhances the promoter activity of MeCP2, but does not enhance the mRNA and protein levels of MeCP2. These results suggest that post-transcriptional mechanisms may play a role in MeCP2 expression.

AB - JC virus (JCV) is a causative agent of progressive multifocal leukoencephalopathy (PML). Methyl CpG binding protein 2 (MeCP2) is a transcriptional control nuclear protein that is abundantly expressed in neurons. We previously observed that the MeCP2 protein is expressed in JCV large T antigen (TAg)-expressing glial cells in PML brains. To investigate the relationship between MeCP2 and JCV TAg, we examined the promoter activity and mRNA and protein expression levels of MeCP2 in JCV TAg-expressing cells. We found that JCV TAg enhances the promoter activity of MeCP2, but does not enhance the mRNA and protein levels of MeCP2. These results suggest that post-transcriptional mechanisms may play a role in MeCP2 expression.

UR - http://www.scopus.com/inward/record.url?scp=84875352458&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875352458&partnerID=8YFLogxK

U2 - 10.7883/yoken.66.126

DO - 10.7883/yoken.66.126

M3 - Article

C2 - 23514909

AN - SCOPUS:84875352458

VL - 66

SP - 126

EP - 132

JO - Japanese Journal of Infectious Diseases

JF - Japanese Journal of Infectious Diseases

SN - 1344-6304

IS - 2

ER -