Relationship between Methyl CpG binding protein 2 and JC viral proteins

Kenta Takahashi; Yasuko Orba; Taichi Kimura; Lei Wang; Shinji Kohsaka; Masumi Tsuda; Mishie Tanino; Hiroshi Nishihara; Kazuo Nagashima; Hirofumi Sawa; Shinya Tanaka

doi:10.7883/yoken.66.126

Relationship between Methyl CpG binding protein 2 and JC viral proteins

Kenta Takahashi, Yasuko Orba, Taichi Kimura, Lei Wang, Shinji Kohsaka, Masumi Tsuda, Mishie Tanino, Hiroshi Nishihara, Kazuo Nagashima, Hirofumi Sawa, Shinya Tanaka

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

JC virus (JCV) is a causative agent of progressive multifocal leukoencephalopathy (PML). Methyl CpG binding protein 2 (MeCP2) is a transcriptional control nuclear protein that is abundantly expressed in neurons. We previously observed that the MeCP2 protein is expressed in JCV large T antigen (TAg)-expressing glial cells in PML brains. To investigate the relationship between MeCP2 and JCV TAg, we examined the promoter activity and mRNA and protein expression levels of MeCP2 in JCV TAg-expressing cells. We found that JCV TAg enhances the promoter activity of MeCP2, but does not enhance the mRNA and protein levels of MeCP2. These results suggest that post-transcriptional mechanisms may play a role in MeCP2 expression.

Original language	English
Pages (from-to)	126-132
Number of pages	7
Journal	Japanese Journal of Infectious Diseases
Volume	66
Issue number	2
DOIs	https://doi.org/10.7883/yoken.66.126
Publication status	Published - 2013
Externally published	Yes

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.7883/yoken.66.126

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title = "Relationship between Methyl CpG binding protein 2 and JC viral proteins",

abstract = "JC virus (JCV) is a causative agent of progressive multifocal leukoencephalopathy (PML). Methyl CpG binding protein 2 (MeCP2) is a transcriptional control nuclear protein that is abundantly expressed in neurons. We previously observed that the MeCP2 protein is expressed in JCV large T antigen (TAg)-expressing glial cells in PML brains. To investigate the relationship between MeCP2 and JCV TAg, we examined the promoter activity and mRNA and protein expression levels of MeCP2 in JCV TAg-expressing cells. We found that JCV TAg enhances the promoter activity of MeCP2, but does not enhance the mRNA and protein levels of MeCP2. These results suggest that post-transcriptional mechanisms may play a role in MeCP2 expression.",

author = "Kenta Takahashi and Yasuko Orba and Taichi Kimura and Lei Wang and Shinji Kohsaka and Masumi Tsuda and Mishie Tanino and Hiroshi Nishihara and Kazuo Nagashima and Hirofumi Sawa and Shinya Tanaka",

year = "2013",

doi = "10.7883/yoken.66.126",

language = "English",

volume = "66",

pages = "126--132",

journal = "Japanese medical journal",

issn = "1344-6304",

publisher = "National Institute of Health",

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}

TY - JOUR

T1 - Relationship between Methyl CpG binding protein 2 and JC viral proteins

AU - Takahashi, Kenta

AU - Orba, Yasuko

AU - Kimura, Taichi

AU - Wang, Lei

AU - Kohsaka, Shinji

AU - Tsuda, Masumi

AU - Tanino, Mishie

AU - Nishihara, Hiroshi

AU - Nagashima, Kazuo

AU - Sawa, Hirofumi

AU - Tanaka, Shinya

PY - 2013

Y1 - 2013

N2 - JC virus (JCV) is a causative agent of progressive multifocal leukoencephalopathy (PML). Methyl CpG binding protein 2 (MeCP2) is a transcriptional control nuclear protein that is abundantly expressed in neurons. We previously observed that the MeCP2 protein is expressed in JCV large T antigen (TAg)-expressing glial cells in PML brains. To investigate the relationship between MeCP2 and JCV TAg, we examined the promoter activity and mRNA and protein expression levels of MeCP2 in JCV TAg-expressing cells. We found that JCV TAg enhances the promoter activity of MeCP2, but does not enhance the mRNA and protein levels of MeCP2. These results suggest that post-transcriptional mechanisms may play a role in MeCP2 expression.

AB - JC virus (JCV) is a causative agent of progressive multifocal leukoencephalopathy (PML). Methyl CpG binding protein 2 (MeCP2) is a transcriptional control nuclear protein that is abundantly expressed in neurons. We previously observed that the MeCP2 protein is expressed in JCV large T antigen (TAg)-expressing glial cells in PML brains. To investigate the relationship between MeCP2 and JCV TAg, we examined the promoter activity and mRNA and protein expression levels of MeCP2 in JCV TAg-expressing cells. We found that JCV TAg enhances the promoter activity of MeCP2, but does not enhance the mRNA and protein levels of MeCP2. These results suggest that post-transcriptional mechanisms may play a role in MeCP2 expression.

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VL - 66

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EP - 132

JO - Japanese medical journal

JF - Japanese medical journal

SN - 1344-6304

IS - 2

ER -

Relationship between Methyl CpG binding protein 2 and JC viral proteins

Abstract

ASJC Scopus subject areas

UN SDGs

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