TY - JOUR
T1 - Relationship between Methyl CpG binding protein 2 and JC viral proteins
AU - Takahashi, Kenta
AU - Orba, Yasuko
AU - Kimura, Taichi
AU - Wang, Lei
AU - Kohsaka, Shinji
AU - Tsuda, Masumi
AU - Tanino, Mishie
AU - Nishihara, Hiroshi
AU - Nagashima, Kazuo
AU - Sawa, Hirofumi
AU - Tanaka, Shinya
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2013
Y1 - 2013
N2 - JC virus (JCV) is a causative agent of progressive multifocal leukoencephalopathy (PML). Methyl CpG binding protein 2 (MeCP2) is a transcriptional control nuclear protein that is abundantly expressed in neurons. We previously observed that the MeCP2 protein is expressed in JCV large T antigen (TAg)-expressing glial cells in PML brains. To investigate the relationship between MeCP2 and JCV TAg, we examined the promoter activity and mRNA and protein expression levels of MeCP2 in JCV TAg-expressing cells. We found that JCV TAg enhances the promoter activity of MeCP2, but does not enhance the mRNA and protein levels of MeCP2. These results suggest that post-transcriptional mechanisms may play a role in MeCP2 expression.
AB - JC virus (JCV) is a causative agent of progressive multifocal leukoencephalopathy (PML). Methyl CpG binding protein 2 (MeCP2) is a transcriptional control nuclear protein that is abundantly expressed in neurons. We previously observed that the MeCP2 protein is expressed in JCV large T antigen (TAg)-expressing glial cells in PML brains. To investigate the relationship between MeCP2 and JCV TAg, we examined the promoter activity and mRNA and protein expression levels of MeCP2 in JCV TAg-expressing cells. We found that JCV TAg enhances the promoter activity of MeCP2, but does not enhance the mRNA and protein levels of MeCP2. These results suggest that post-transcriptional mechanisms may play a role in MeCP2 expression.
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U2 - 10.7883/yoken.66.126
DO - 10.7883/yoken.66.126
M3 - Article
C2 - 23514909
AN - SCOPUS:84875352458
VL - 66
SP - 126
EP - 132
JO - Japanese Journal of Infectious Diseases
JF - Japanese Journal of Infectious Diseases
SN - 1344-6304
IS - 2
ER -