Abstract
JC virus (JCV) is a causative agent of progressive multifocal leukoencephalopathy (PML). Methyl CpG binding protein 2 (MeCP2) is a transcriptional control nuclear protein that is abundantly expressed in neurons. We previously observed that the MeCP2 protein is expressed in JCV large T antigen (TAg)-expressing glial cells in PML brains. To investigate the relationship between MeCP2 and JCV TAg, we examined the promoter activity and mRNA and protein expression levels of MeCP2 in JCV TAg-expressing cells. We found that JCV TAg enhances the promoter activity of MeCP2, but does not enhance the mRNA and protein levels of MeCP2. These results suggest that post-transcriptional mechanisms may play a role in MeCP2 expression.
| Original language | English |
|---|---|
| Pages (from-to) | 126-132 |
| Number of pages | 7 |
| Journal | Japanese Journal of Infectious Diseases |
| Volume | 66 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2013 Mar 28 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases
Cite this
Relationship between Methyl CpG binding protein 2 and JC viral proteins. / Takahashi, Kenta; Orba, Yasuko; Kimura, Taichi; Wang, Lei; Kohsaka, Shinji; Tsuda, Masumi; Tanino, Mishie; Nishihara, Hiroshi; Nagashima, Kazuo; Sawa, Hirofumi; Tanaka, Shinya.
In: Japanese Journal of Infectious Diseases, Vol. 66, No. 2, 28.03.2013, p. 126-132.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Relationship between Methyl CpG binding protein 2 and JC viral proteins
AU - Takahashi, Kenta
AU - Orba, Yasuko
AU - Kimura, Taichi
AU - Wang, Lei
AU - Kohsaka, Shinji
AU - Tsuda, Masumi
AU - Tanino, Mishie
AU - Nishihara, Hiroshi
AU - Nagashima, Kazuo
AU - Sawa, Hirofumi
AU - Tanaka, Shinya
PY - 2013/3/28
Y1 - 2013/3/28
N2 - JC virus (JCV) is a causative agent of progressive multifocal leukoencephalopathy (PML). Methyl CpG binding protein 2 (MeCP2) is a transcriptional control nuclear protein that is abundantly expressed in neurons. We previously observed that the MeCP2 protein is expressed in JCV large T antigen (TAg)-expressing glial cells in PML brains. To investigate the relationship between MeCP2 and JCV TAg, we examined the promoter activity and mRNA and protein expression levels of MeCP2 in JCV TAg-expressing cells. We found that JCV TAg enhances the promoter activity of MeCP2, but does not enhance the mRNA and protein levels of MeCP2. These results suggest that post-transcriptional mechanisms may play a role in MeCP2 expression.
AB - JC virus (JCV) is a causative agent of progressive multifocal leukoencephalopathy (PML). Methyl CpG binding protein 2 (MeCP2) is a transcriptional control nuclear protein that is abundantly expressed in neurons. We previously observed that the MeCP2 protein is expressed in JCV large T antigen (TAg)-expressing glial cells in PML brains. To investigate the relationship between MeCP2 and JCV TAg, we examined the promoter activity and mRNA and protein expression levels of MeCP2 in JCV TAg-expressing cells. We found that JCV TAg enhances the promoter activity of MeCP2, but does not enhance the mRNA and protein levels of MeCP2. These results suggest that post-transcriptional mechanisms may play a role in MeCP2 expression.
UR - http://www.scopus.com/inward/record.url?scp=84875352458&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875352458&partnerID=8YFLogxK
U2 - 10.7883/yoken.66.126
DO - 10.7883/yoken.66.126
M3 - Article
VL - 66
SP - 126
EP - 132
JO - Japanese Journal of Infectious Diseases
JF - Japanese Journal of Infectious Diseases
SN - 1344-6304
IS - 2
ER -