Relationship between Methyl CpG binding protein 2 and JC viral proteins

Kenta Takahashi, Yasuko Orba, Taichi Kimura, Lei Wang, Shinji Kohsaka, Masumi Tsuda, Mishie Tanino, Hiroshi Nishihara, Kazuo Nagashima, Hirofumi Sawa, Shinya Tanaka

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Abstract

JC virus (JCV) is a causative agent of progressive multifocal leukoencephalopathy (PML). Methyl CpG binding protein 2 (MeCP2) is a transcriptional control nuclear protein that is abundantly expressed in neurons. We previously observed that the MeCP2 protein is expressed in JCV large T antigen (TAg)-expressing glial cells in PML brains. To investigate the relationship between MeCP2 and JCV TAg, we examined the promoter activity and mRNA and protein expression levels of MeCP2 in JCV TAg-expressing cells. We found that JCV TAg enhances the promoter activity of MeCP2, but does not enhance the mRNA and protein levels of MeCP2. These results suggest that post-transcriptional mechanisms may play a role in MeCP2 expression.

Original languageEnglish
Pages (from-to)126-132
Number of pages7
JournalJapanese Journal of Infectious Diseases
Volume66
Issue number2
DOIs
Publication statusPublished - 2013 Mar 28
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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    Takahashi, K., Orba, Y., Kimura, T., Wang, L., Kohsaka, S., Tsuda, M., Tanino, M., Nishihara, H., Nagashima, K., Sawa, H., & Tanaka, S. (2013). Relationship between Methyl CpG binding protein 2 and JC viral proteins. Japanese Journal of Infectious Diseases, 66(2), 126-132. https://doi.org/10.7883/yoken.66.126