Relationship between mood episode and employment status of outpatients with bipolar disorder: Retrospective cohort study from the multicenter treatment survey for bipolar disorder in psychiatric clinics (musubi) project

Yusuke Konno, Yoshihisa Fujino, Atsuko Ikenouchi, Naoto Adachi, Yukihisa Kubota, Takaharu Azekawa, Hitoshi Ueda, Koji Edagawa, Eiichi Katsumoto, Eiichiro Goto, Seiji Hongo, Masaki Kato, Takashi Tsuboi, Norio Yasui-Furukori, Atsuo Nakagawa, Toshiaki Kikuchi, Koichiro Watanabe, Reiji Yoshimura

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The objective of this study was to clarify the relationship between mood episode and employment in patients with bipolar disorder to help improve their employment status. Methods: All medical records of patients with bipolar disorder who visited 176 member clinics of the Japanese Association of Neuro-Psychiatric Clinics in September-October 2016 were investigated in September-October 2017. Details of the medical care received were investigated using a survey sheet, which included employment status. Odds ratios of mood episodes for employment status were analyzed using a logistic regression model. Results: Among patients aged 60 years or less, 2292 described their occupation. On univariate analysis, odds ratios were statistically significant for depressive episode (OR=2.68 [1.50-4.78] p=0.001) and manic episode (OR=2.64 [1.07-6.47] p=0.034), whereas no significant difference was noted for mixed episode (OR=1.72 [0.69-4.33] p=0.246). On multivariate analysis, odds ratios were statistically significant for depressive episode (OR=2.16 [1.13-4.13], p=0.020) and manic episode (OR=3.55 [1.36-9.25], p=0.010), whereas no significant difference was noted for mixed episode (OR=1.83 [0.65-5.14] p=0.254). Conclusion: Employment status among these patients with bipolar disorder receiving outpatient treatment was 43.5%. Compared to remission episodes, manic and depressive episodes were associated with a higher risk of unemployment.

Original languageEnglish
Pages (from-to)2867-2876
Number of pages10
JournalNeuropsychiatric Disease and Treatment
Volume17
DOIs
Publication statusPublished - 2021

Keywords

  • Continuous employment
  • Japan
  • Mood disorder
  • Occupational health

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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