Relationship between nerve fiber layer defect and the presence of epiretinal membrane in a Japanese population: The JPHC-NEXT Eye Study

Atsuro Uchida, Mariko Sasaki, Kaoru Motomura, Kenya Yuki, Toshihide Kurihara, Yohei Tomita, Yoko Ozawa, Kazumasa Yamagishi, Ryo Kawasaki, Akiko Hanyuda, Norie Sawada, Kazuo Tsubota, Shoichiro Tsugane, Hiroyasu Iso

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The study subjects were residents of Chikusei city, Japan, aged 40 years or older who attended annual health check-up programs and participated in the JPHC-NEXT Eye Study which performed non-mydriatic fundus photography of both eyes. The relationship of glaucomatous fundus changes such as optic disc cupping (cup to disc ratio ≥ 0.7) and retinal nerve fiber layer defect (NFLD) with the presence of epiretinal membrane (ERM) were examined cross-sectionally. A total of 1990 persons gave consent to participate in this study in 2013. The overall prevalence of ERM was 12.9%. Of these, 1755 had fundus photographs of sufficient quality and no history of intraocular surgery (mean age: 62.3 ± 10.0 years). After adjusting for age, sex and refractive error, NFLD was positively associated with the presence of ERM (odds ratio [OR]: 2.48; 95% confidence interval [CI]: 1.24, 4.96; P = 0.010), but optic disc cupping was not (OR: 1.33; CI: 0.71, 2.48; P = 0.37). The results did not necessarily suggest an association between glaucoma and ERM, but indicated an association between NFLD and ERM.

Original languageEnglish
Article number779
JournalScientific reports
Issue number1
Publication statusPublished - 2020 Dec 1


ASJC Scopus subject areas

  • General

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