Relationship between pupil size and acetylcholinesterase activity in patients exposed to sarin vapor

H. Nozaki, S. Hori, Y. Shinozawa, Seitaro Fujishima, K. Takuma, H. Kimura, M. Suzuki, N. Aikawa

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Objective: To elucidate the effect of sarin vapor on pupil size and erythrocyte acetylcholinesterase activity (AchE). Design: Retrospective observational survey. Setting: Emergency department of an urban teaching hospital. Patients: 80 patients who were exposed to sarin in a terrorist attack in Tokyo subways. Measurements and results: Pupil size and AchE activity on the day of exposure were measured. Among the 8O patients, the pupils were miotic ( < 3 mm) in 50 patients (62.5%), while AchE activity was below the normal range ( < 1.2 U) in 34 patients (42.5%). AchE was significantly lower in the miotic group than in the group with normal pupils (1.0 ± 0.5 U vs 1.5 ± 0.3 U, p < 0.01). In the miotic group, AchE activity was lower than normal in 32 patients (64.0%) but was decreased in only 2 patients in the normal pupil group (6.7%) (p < 0.01). Conclusions: Miosis is a more sensitive index of exposure to sarin vapor than erythrocyte AchE. Systemic poisoning is apparently less likely to develop if the patient's pupil size is normal on arrival at the hospital.

Original languageEnglish
Pages (from-to)1005-1007
Number of pages3
JournalIntensive Care Medicine
Volume23
Issue number9
DOIs
Publication statusPublished - 1997

Fingerprint

Sarin
Acetylcholinesterase
Pupil
Miotics
Erythrocytes
Railroads
Miosis
Tokyo
Urban Hospitals
Teaching Hospitals
Poisoning
Hospital Emergency Service
Reference Values

Keywords

  • Acetylcholinesterase
  • Cholinesterase
  • Miosis
  • Nerve agent
  • Organophosphate
  • Sarin

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Relationship between pupil size and acetylcholinesterase activity in patients exposed to sarin vapor. / Nozaki, H.; Hori, S.; Shinozawa, Y.; Fujishima, Seitaro; Takuma, K.; Kimura, H.; Suzuki, M.; Aikawa, N.

In: Intensive Care Medicine, Vol. 23, No. 9, 1997, p. 1005-1007.

Research output: Contribution to journalArticle

Nozaki, H, Hori, S, Shinozawa, Y, Fujishima, S, Takuma, K, Kimura, H, Suzuki, M & Aikawa, N 1997, 'Relationship between pupil size and acetylcholinesterase activity in patients exposed to sarin vapor', Intensive Care Medicine, vol. 23, no. 9, pp. 1005-1007. https://doi.org/10.1007/s001340050447
Nozaki, H. ; Hori, S. ; Shinozawa, Y. ; Fujishima, Seitaro ; Takuma, K. ; Kimura, H. ; Suzuki, M. ; Aikawa, N. / Relationship between pupil size and acetylcholinesterase activity in patients exposed to sarin vapor. In: Intensive Care Medicine. 1997 ; Vol. 23, No. 9. pp. 1005-1007.
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