Relationship between [18F]FDG PET/CT and metabolomics in patients with colorectal cancer

Masashi Imajo, Takashi Norikane, Yuka Yamamoto, Yukito Maeda, Kaori Saitoh, Keiko Kato, Tomoyoshi Soga, Keiichi Okano, Yoshihiro Nishiyama

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Advances in metabolomics have significantly improved cancer detection, diagnosis, treatment, and prognosis. Objectives: To investigate the relationship between metabolic tumor volume (MTV) using 2-deoxy-2-[18F]fluoro-D-glucose (FDG) positron emission tomography (PET)/ computed tomography (CT) and metabolomics data in patients with colorectal cancer (CRC). Methods: The metabolome in tumor tissues was analyzed using capillary electrophoresis time-of-flight mass spectrometry in 33 patients with newly diagnosed CRC who underwent FDG PET/CT before treatment and had tumor tissue post-surgery. Based on the FDG PET data, MTV was calculated and was dichotomized according to the median value, and tumors were divided into low-MTV and high-MTV tumors. Metabolomics data were compared between the low-MTV and high-MTV tumors. Results: The levels of most glycolysis-related metabolites were not different between low-MTV and high-MTV tumors. The level of component of the initial part of the tricarboxylic acid (TCA) cycle, citrate, was significantly lower in the high-MTV tumor than in the low-MTV tumor. The TCA intermediate succinate level was significantly higher in the high-MTV tumor than in the low-MTV tumor. In contrast, the TCA intermediate fumarate level was significantly lower in the high-MTV tumor than in the low-MTV tumor. The levels of many amino acids were significantly higher in the high-MTV tumor than in the low-MTV tumor. Conclusions: Although preliminary, these results suggest that tumors with high FDG metabolism in CRC may obtain more energy by using a reverse reaction of the TCA cycle and amino-acid metabolism. However, further research is required to clarify this relationship.

Original languageEnglish
Article number91
JournalMetabolomics
Volume18
Issue number11
DOIs
Publication statusPublished - 2022 Nov

Keywords

  • Colorectal cancer
  • FDG
  • Metabolome
  • PET/CT

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Clinical Biochemistry

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