Relationship between the blood coagulation-fibrinolysis system and the subclinical indicators of arteriosclerosis in a healthy male population.

Y. Nishiwaki, T. Takebayashi, K. Omae, C. Ishizuka, T. Nomiyama, H. Sakurai

Research output: Contribution to journalArticle

Abstract

A cross-sectional observation was performed to assess the relationship between the coagulation-fibrinolysis system and the subclinical indicators of arteriosclerosis in a healthy male population. Subjects were 445 workers (18.9-49.4, Av. 36.2 yrs) in viscose rayon manufacturing factories in Japan. Coagulation-fibrinolysis parameters determined were D-dimer(DD), thrombin antithrombin III complex (TAT), tissue plasminogen activator (TPA), and plasminogen activator inhibitor 1 (PAI1). The following indicators of arteriosclerosis were examined; systolic and diastolic blood pressure (SBP, DBP), stiffness parameter of the carotid artery using ultrasound (beta), pulse wave velocity of the aorta (PWV), and a number of lacunar infarctions from brain MRI. After age-stratification(-29, 30-39, 40+ yrs), the subjects were classified into quartiles by coagulation-fibrinolysis parameters. The mean values of SBP and DBP and beta and PWV, the prevalence of brain infarctions were compared across these quartiles by means of analysis of variance, chi-square test, respectively. Multivariate analysis was also employed to adjust other risk factors. In conclusion, SBP and DBP and beta, PWV were elevated by increase of PAI1, TAT, respectively, in the 40+ years group even after adjustment for other possible risk factors. DD had no relation to any of the indicators of arteriosclerosis. None of the coagulation-fibrinolysis parameters had any relation to brain infarctions.

Original languageEnglish
Pages (from-to)34-41
Number of pages8
JournalJournal of epidemiology / Japan Epidemiological Association
Volume10
Issue number1
Publication statusPublished - 2000 Jan

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Arteriosclerosis
Blood Coagulation
Fibrinolysis
Pulse Wave Analysis
Brain Infarction
Aorta
Plasminogen Activator Inhibitor 1
Population
Blood Pressure
Lacunar Stroke
Tissue Plasminogen Activator
Chi-Square Distribution
Carotid Arteries
Analysis of Variance
Japan
Multivariate Analysis
Observation
Brain
fibrin fragment D

ASJC Scopus subject areas

  • Epidemiology

Cite this

Relationship between the blood coagulation-fibrinolysis system and the subclinical indicators of arteriosclerosis in a healthy male population. / Nishiwaki, Y.; Takebayashi, T.; Omae, K.; Ishizuka, C.; Nomiyama, T.; Sakurai, H.

In: Journal of epidemiology / Japan Epidemiological Association, Vol. 10, No. 1, 01.2000, p. 34-41.

Research output: Contribution to journalArticle

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