Abstract
Characteristics of glucose metabolism in subjects with white-coat hypertension (WCHT) have not been fully investigated. The purpose of this study was to determine the relationship between glucose metabolism and WCHT on the basis of blood pressure (BP) at home (HBP) in the general population. Participants were from Ohasama, a rural Japanese community, and included 466 residents (mean age, 61.0 years) who had no history of diabetes mellitus. HBP and oral glucose tolerance test values were measured. Participants were classified into four groups on the basis of their HBP and casual-screening BP (CBP) values: normotension (NT) (HBP<135/85 mm Hg, CBP<140/90 mm Hg); WCHT (HBP<135/85 mm Hg, CBP≥140/90 mm Hg); masked hypertension (HBP≥135/85 mm Hg, CBP≥140/90 mm Hg); or sustained hypertension (SHT) (HBP≥135/85 mm Hg, CBP≥140/90 mm Hg). The relationships between glucose metabolism and BP among the four groups were examined using multivariate analysis adjusted for possible confounding factors. Factors in relation to glucose metabolism, such as fasting glucose level, 2-h postchallenge glucose level and homeostasis model assessment-insulin resistance index, were significantly higher in subjects with WCHT and SHT than in those with NT (all P<0.03). When men and women were analyzed separately, these relationships were more pronounced in women. Our results suggest that dysregulation of glucose metabolism in WCHT might contribute to the increase in the long-term cardiovascular risk among the general population.
| Original language | English |
|---|---|
| Pages (from-to) | 937-943 |
| Number of pages | 7 |
| Journal | Hypertension Research |
| Volume | 33 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2010 Sep 1 |
| Externally published | Yes |
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Keywords
- general population
- glucose metabolism
- home blood pressure
- oral glucose tolerance test
- white-coat hypertension
ASJC Scopus subject areas
- Internal Medicine
- Physiology
- Cardiology and Cardiovascular Medicine
Cite this
Relationship of dysregulation of glucose metabolism with white-coat hypertension : The Ohasama study. / Hosaka, Miki; Mimura, Akira; Asayama, Kei; Ohkubo, Takayoshi; Hayashi, Katsuhisa; Kikuya, Masahiro; Sato, Michihiro; Hashimoto, Takanao; Kanno, Atsuhiro; Hara, Azusa; Obara, Taku; Metoki, Hirohito; Inoue, Ryusuke; Hoshi, Haruhisa; Satoh, Hiroshi; Oka, Yoshitomo; Imai, Yutaka.
In: Hypertension Research, Vol. 33, No. 9, 01.09.2010, p. 937-943.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Relationship of dysregulation of glucose metabolism with white-coat hypertension
T2 - The Ohasama study
AU - Hosaka, Miki
AU - Mimura, Akira
AU - Asayama, Kei
AU - Ohkubo, Takayoshi
AU - Hayashi, Katsuhisa
AU - Kikuya, Masahiro
AU - Sato, Michihiro
AU - Hashimoto, Takanao
AU - Kanno, Atsuhiro
AU - Hara, Azusa
AU - Obara, Taku
AU - Metoki, Hirohito
AU - Inoue, Ryusuke
AU - Hoshi, Haruhisa
AU - Satoh, Hiroshi
AU - Oka, Yoshitomo
AU - Imai, Yutaka
PY - 2010/9/1
Y1 - 2010/9/1
N2 - Characteristics of glucose metabolism in subjects with white-coat hypertension (WCHT) have not been fully investigated. The purpose of this study was to determine the relationship between glucose metabolism and WCHT on the basis of blood pressure (BP) at home (HBP) in the general population. Participants were from Ohasama, a rural Japanese community, and included 466 residents (mean age, 61.0 years) who had no history of diabetes mellitus. HBP and oral glucose tolerance test values were measured. Participants were classified into four groups on the basis of their HBP and casual-screening BP (CBP) values: normotension (NT) (HBP<135/85 mm Hg, CBP<140/90 mm Hg); WCHT (HBP<135/85 mm Hg, CBP≥140/90 mm Hg); masked hypertension (HBP≥135/85 mm Hg, CBP≥140/90 mm Hg); or sustained hypertension (SHT) (HBP≥135/85 mm Hg, CBP≥140/90 mm Hg). The relationships between glucose metabolism and BP among the four groups were examined using multivariate analysis adjusted for possible confounding factors. Factors in relation to glucose metabolism, such as fasting glucose level, 2-h postchallenge glucose level and homeostasis model assessment-insulin resistance index, were significantly higher in subjects with WCHT and SHT than in those with NT (all P<0.03). When men and women were analyzed separately, these relationships were more pronounced in women. Our results suggest that dysregulation of glucose metabolism in WCHT might contribute to the increase in the long-term cardiovascular risk among the general population.
AB - Characteristics of glucose metabolism in subjects with white-coat hypertension (WCHT) have not been fully investigated. The purpose of this study was to determine the relationship between glucose metabolism and WCHT on the basis of blood pressure (BP) at home (HBP) in the general population. Participants were from Ohasama, a rural Japanese community, and included 466 residents (mean age, 61.0 years) who had no history of diabetes mellitus. HBP and oral glucose tolerance test values were measured. Participants were classified into four groups on the basis of their HBP and casual-screening BP (CBP) values: normotension (NT) (HBP<135/85 mm Hg, CBP<140/90 mm Hg); WCHT (HBP<135/85 mm Hg, CBP≥140/90 mm Hg); masked hypertension (HBP≥135/85 mm Hg, CBP≥140/90 mm Hg); or sustained hypertension (SHT) (HBP≥135/85 mm Hg, CBP≥140/90 mm Hg). The relationships between glucose metabolism and BP among the four groups were examined using multivariate analysis adjusted for possible confounding factors. Factors in relation to glucose metabolism, such as fasting glucose level, 2-h postchallenge glucose level and homeostasis model assessment-insulin resistance index, were significantly higher in subjects with WCHT and SHT than in those with NT (all P<0.03). When men and women were analyzed separately, these relationships were more pronounced in women. Our results suggest that dysregulation of glucose metabolism in WCHT might contribute to the increase in the long-term cardiovascular risk among the general population.
KW - general population
KW - glucose metabolism
KW - home blood pressure
KW - oral glucose tolerance test
KW - white-coat hypertension
UR - http://www.scopus.com/inward/record.url?scp=77956417425&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77956417425&partnerID=8YFLogxK
U2 - 10.1038/hr.2010.114
DO - 10.1038/hr.2010.114
M3 - Article
C2 - 20631718
AN - SCOPUS:77956417425
VL - 33
SP - 937
EP - 943
JO - Hypertension Research
JF - Hypertension Research
SN - 0916-9636
IS - 9
ER -