Relationships between Composition of Major Fatty Acids and Fat Distribution and Insulin Resistance in Japanese

Chikako Fujii, Toshihide Kawai, Koichiro Azuma, Yuko Oguma, Fuminori Katsukawa, Hiroshi Hirose, Kumiko Tanaka, Shu Meguro, Hideo Matsumoto, Hiroshi Itoh

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Abstract

Objective. The aim of this study was to evaluate the relationships between the composition of free fatty acids (FFAs) and metabolic parameters, including body fat distribution, in Japanese. Methods. The study subjects were 111 Japanese patients (54 males, 57 females). Metabolic parameters and visceral and subcutaneous fat areas as determined by CT scanning at the umbilical level were measured. Glucose tolerance test (GTT) was performed by administering 75 g glucose orally. Results. The percentage of linoleic acid (C18:2), the greatest constituent among FFAs, was negatively correlated with visceral fat area (r=-0.411, p<0.0001), fasting glucose (r=-0.330, p<0.0001), HbA1c (r=-0.231, p=0.0146), and systolic blood pressure (r=-0.224, p=0.0184). Linoleic acid percentage was also significantly negatively correlated with HOMA-IR (r=-0.416, p<0.0001) by simple correlation. Based on the findings of OGTT, the 111 subjects were classified into three groups: 33 with normal glucose tolerance, 71 with impaired glucose tolerance (IGT), and 7 diabetic subjects. The percentage of serum linoleic acid in diabetic subjects was significantly lower than that in normal subjects. Conclusion. We conclude that serum linoleic acid level is negatively correlated with the accumulation of visceral fat in relation to a reduction of insulin resistance in Japanese subjects.

Original languageEnglish
Article number1567467
JournalJournal of Diabetes Research
Volume2017
DOIs
Publication statusPublished - 2017

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Linoleic Acid
Intra-Abdominal Fat
Insulin Resistance
Fatty Acids
Fats
Glucose Tolerance Test
Nonesterified Fatty Acids
Glucose
Blood Pressure
Body Fat Distribution
Umbilicus
Glucose Intolerance
Subcutaneous Fat
Serum
Fasting

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Relationships between Composition of Major Fatty Acids and Fat Distribution and Insulin Resistance in Japanese. / Fujii, Chikako; Kawai, Toshihide; Azuma, Koichiro; Oguma, Yuko; Katsukawa, Fuminori; Hirose, Hiroshi; Tanaka, Kumiko; Meguro, Shu; Matsumoto, Hideo; Itoh, Hiroshi.

In: Journal of Diabetes Research, Vol. 2017, 1567467, 2017.

Research output: Contribution to journalArticle

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AU - Katsukawa, Fuminori

AU - Hirose, Hiroshi

AU - Tanaka, Kumiko

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