Relationships of Drosophila melanogaster RECQ5/QE to cell-cycle progression and DNA damage

Minoru Nakayama, Sayako Maruyama, Hiroshi Kanda, Noriko Ohkita, Katsunori Nakano, Fumiaki Ito, Katsumi Kawasaki

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Members of the RecQ family of DNA helicases are involved in the cellular response to DNA damage and are regulated in the cell-cycle. However, little is known about RecQ5, one of these members. The level of RECQ5/QE, Drosophila melanogaster RecQ5, was increased after the exposure of cultured cells to methyl-methanesulfonate. Transgenic flies that overexpressed RECQ5/QE in their developing eye primordia showed mild roughening of the ommatidial lattice. DNA-damaging agents and the mei-41 mutation enhanced the phenotype caused by RECQ5/QE overexpression. Overexpression of RECQ5/QE perturbed the progression of the cell-cycle in response to DNA damage in the eye imaginal discs. These results suggest that RECQ5/QE interacts with components of the cell-cycle during its progression in response to DNA damage.

Original languageEnglish
Pages (from-to)6938-6942
Number of pages5
JournalFEBS Letters
Volume580
Issue number30
DOIs
Publication statusPublished - 2006 Dec 22
Externally publishedYes

Fingerprint

Drosophila melanogaster
DNA Damage
Cell Cycle
Cells
DNA
RecQ Helicases
Imaginal Discs
Methyl Methanesulfonate
Diptera
Cultured Cells
Phenotype
Mutation

Keywords

  • Drosophila melanogaster
  • Genome stability
  • Helicase
  • RecQ
  • Repair

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Nakayama, M., Maruyama, S., Kanda, H., Ohkita, N., Nakano, K., Ito, F., & Kawasaki, K. (2006). Relationships of Drosophila melanogaster RECQ5/QE to cell-cycle progression and DNA damage. FEBS Letters, 580(30), 6938-6942. https://doi.org/10.1016/j.febslet.2006.11.059

Relationships of Drosophila melanogaster RECQ5/QE to cell-cycle progression and DNA damage. / Nakayama, Minoru; Maruyama, Sayako; Kanda, Hiroshi; Ohkita, Noriko; Nakano, Katsunori; Ito, Fumiaki; Kawasaki, Katsumi.

In: FEBS Letters, Vol. 580, No. 30, 22.12.2006, p. 6938-6942.

Research output: Contribution to journalArticle

Nakayama, M, Maruyama, S, Kanda, H, Ohkita, N, Nakano, K, Ito, F & Kawasaki, K 2006, 'Relationships of Drosophila melanogaster RECQ5/QE to cell-cycle progression and DNA damage', FEBS Letters, vol. 580, no. 30, pp. 6938-6942. https://doi.org/10.1016/j.febslet.2006.11.059
Nakayama, Minoru ; Maruyama, Sayako ; Kanda, Hiroshi ; Ohkita, Noriko ; Nakano, Katsunori ; Ito, Fumiaki ; Kawasaki, Katsumi. / Relationships of Drosophila melanogaster RECQ5/QE to cell-cycle progression and DNA damage. In: FEBS Letters. 2006 ; Vol. 580, No. 30. pp. 6938-6942.
@article{0754be844c64469e902985890957bec8,
title = "Relationships of Drosophila melanogaster RECQ5/QE to cell-cycle progression and DNA damage",
abstract = "Members of the RecQ family of DNA helicases are involved in the cellular response to DNA damage and are regulated in the cell-cycle. However, little is known about RecQ5, one of these members. The level of RECQ5/QE, Drosophila melanogaster RecQ5, was increased after the exposure of cultured cells to methyl-methanesulfonate. Transgenic flies that overexpressed RECQ5/QE in their developing eye primordia showed mild roughening of the ommatidial lattice. DNA-damaging agents and the mei-41 mutation enhanced the phenotype caused by RECQ5/QE overexpression. Overexpression of RECQ5/QE perturbed the progression of the cell-cycle in response to DNA damage in the eye imaginal discs. These results suggest that RECQ5/QE interacts with components of the cell-cycle during its progression in response to DNA damage.",
keywords = "Drosophila melanogaster, Genome stability, Helicase, RecQ, Repair",
author = "Minoru Nakayama and Sayako Maruyama and Hiroshi Kanda and Noriko Ohkita and Katsunori Nakano and Fumiaki Ito and Katsumi Kawasaki",
year = "2006",
month = "12",
day = "22",
doi = "10.1016/j.febslet.2006.11.059",
language = "English",
volume = "580",
pages = "6938--6942",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "30",

}

TY - JOUR

T1 - Relationships of Drosophila melanogaster RECQ5/QE to cell-cycle progression and DNA damage

AU - Nakayama, Minoru

AU - Maruyama, Sayako

AU - Kanda, Hiroshi

AU - Ohkita, Noriko

AU - Nakano, Katsunori

AU - Ito, Fumiaki

AU - Kawasaki, Katsumi

PY - 2006/12/22

Y1 - 2006/12/22

N2 - Members of the RecQ family of DNA helicases are involved in the cellular response to DNA damage and are regulated in the cell-cycle. However, little is known about RecQ5, one of these members. The level of RECQ5/QE, Drosophila melanogaster RecQ5, was increased after the exposure of cultured cells to methyl-methanesulfonate. Transgenic flies that overexpressed RECQ5/QE in their developing eye primordia showed mild roughening of the ommatidial lattice. DNA-damaging agents and the mei-41 mutation enhanced the phenotype caused by RECQ5/QE overexpression. Overexpression of RECQ5/QE perturbed the progression of the cell-cycle in response to DNA damage in the eye imaginal discs. These results suggest that RECQ5/QE interacts with components of the cell-cycle during its progression in response to DNA damage.

AB - Members of the RecQ family of DNA helicases are involved in the cellular response to DNA damage and are regulated in the cell-cycle. However, little is known about RecQ5, one of these members. The level of RECQ5/QE, Drosophila melanogaster RecQ5, was increased after the exposure of cultured cells to methyl-methanesulfonate. Transgenic flies that overexpressed RECQ5/QE in their developing eye primordia showed mild roughening of the ommatidial lattice. DNA-damaging agents and the mei-41 mutation enhanced the phenotype caused by RECQ5/QE overexpression. Overexpression of RECQ5/QE perturbed the progression of the cell-cycle in response to DNA damage in the eye imaginal discs. These results suggest that RECQ5/QE interacts with components of the cell-cycle during its progression in response to DNA damage.

KW - Drosophila melanogaster

KW - Genome stability

KW - Helicase

KW - RecQ

KW - Repair

UR - http://www.scopus.com/inward/record.url?scp=33845466426&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845466426&partnerID=8YFLogxK

U2 - 10.1016/j.febslet.2006.11.059

DO - 10.1016/j.febslet.2006.11.059

M3 - Article

C2 - 17157839

AN - SCOPUS:33845466426

VL - 580

SP - 6938

EP - 6942

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 30

ER -