Relationships of Drosophila melanogaster RECQ5/QE to cell-cycle progression and DNA damage

Minoru Nakayama, Sayako Maruyama, Hiroshi Kanda, Noriko Ohkita, Katsunori Nakano, Fumiaki Ito, Katsumi Kawasaki

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Members of the RecQ family of DNA helicases are involved in the cellular response to DNA damage and are regulated in the cell-cycle. However, little is known about RecQ5, one of these members. The level of RECQ5/QE, Drosophila melanogaster RecQ5, was increased after the exposure of cultured cells to methyl-methanesulfonate. Transgenic flies that overexpressed RECQ5/QE in their developing eye primordia showed mild roughening of the ommatidial lattice. DNA-damaging agents and the mei-41 mutation enhanced the phenotype caused by RECQ5/QE overexpression. Overexpression of RECQ5/QE perturbed the progression of the cell-cycle in response to DNA damage in the eye imaginal discs. These results suggest that RECQ5/QE interacts with components of the cell-cycle during its progression in response to DNA damage.

Original languageEnglish
Pages (from-to)6938-6942
Number of pages5
JournalFEBS Letters
Volume580
Issue number30
DOIs
Publication statusPublished - 2006 Dec 22

Keywords

  • Drosophila melanogaster
  • Genome stability
  • Helicase
  • RecQ
  • Repair

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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