Relative and absolute stereochemistry of the melanogenesis inhibitors OH-3984 K1 and K2. Partial synthesis from albocycline

Toshiaki Sunazuka, Rika Obata, Li Zhuorong, Satoshi Takamatsu, Kanki Komiyama, Satoshi Omura, Amos B. Smith

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The transformation of the macrolide antibiotic albocycline (3) to the recently isolated melanin synthesis inhibitors OH-3984 K1 (1 and K2 (2) has established the relative and absolute configurations of 1 (4R, 7R, 12S) and 2 (4R, 7R, 12S, 13R).

Original languageEnglish
Pages (from-to)2635-2636
Number of pages2
JournalTetrahedron Letters
Volume35
Issue number17
DOIs
Publication statusPublished - 1994 Apr 25
Externally publishedYes

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Stereochemistry
Melanins
Macrolides
Anti-Bacterial Agents
hydroxide ion
albocycline

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Sunazuka, T., Obata, R., Zhuorong, L., Takamatsu, S., Komiyama, K., Omura, S., & Smith, A. B. (1994). Relative and absolute stereochemistry of the melanogenesis inhibitors OH-3984 K1 and K2. Partial synthesis from albocycline. Tetrahedron Letters, 35(17), 2635-2636. https://doi.org/10.1016/S0040-4039(00)76992-9

Relative and absolute stereochemistry of the melanogenesis inhibitors OH-3984 K1 and K2. Partial synthesis from albocycline. / Sunazuka, Toshiaki; Obata, Rika; Zhuorong, Li; Takamatsu, Satoshi; Komiyama, Kanki; Omura, Satoshi; Smith, Amos B.

In: Tetrahedron Letters, Vol. 35, No. 17, 25.04.1994, p. 2635-2636.

Research output: Contribution to journalArticle

Sunazuka, T, Obata, R, Zhuorong, L, Takamatsu, S, Komiyama, K, Omura, S & Smith, AB 1994, 'Relative and absolute stereochemistry of the melanogenesis inhibitors OH-3984 K1 and K2. Partial synthesis from albocycline', Tetrahedron Letters, vol. 35, no. 17, pp. 2635-2636. https://doi.org/10.1016/S0040-4039(00)76992-9
Sunazuka, Toshiaki ; Obata, Rika ; Zhuorong, Li ; Takamatsu, Satoshi ; Komiyama, Kanki ; Omura, Satoshi ; Smith, Amos B. / Relative and absolute stereochemistry of the melanogenesis inhibitors OH-3984 K1 and K2. Partial synthesis from albocycline. In: Tetrahedron Letters. 1994 ; Vol. 35, No. 17. pp. 2635-2636.
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