Relative and absolute stereochemistry of the melanogenesis inhibitors OH-3984 K1 and K2. Partial synthesis from albocycline

Toshiaki Sunazuka, Rika Obata, Li Zhuorong, Satoshi Takamatsu, Kanki Komiyama, Satoshi Omura, Amos B. Smith

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7 Citations (Scopus)

Abstract

The transformation of the macrolide antibiotic albocycline (3) to the recently isolated melanin synthesis inhibitors OH-3984 K1 (1 and K2 (2) has established the relative and absolute configurations of 1 (4R, 7R, 12S) and 2 (4R, 7R, 12S, 13R).

Original languageEnglish
Pages (from-to)2635-2636
Number of pages2
JournalTetrahedron Letters
Volume35
Issue number17
DOIs
Publication statusPublished - 1994 Apr 25

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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    Sunazuka, T., Obata, R., Zhuorong, L., Takamatsu, S., Komiyama, K., Omura, S., & Smith, A. B. (1994). Relative and absolute stereochemistry of the melanogenesis inhibitors OH-3984 K1 and K2. Partial synthesis from albocycline. Tetrahedron Letters, 35(17), 2635-2636. https://doi.org/10.1016/S0040-4039(00)76992-9