Relative antidipsogenic potencies of six homologous natriuretic peptides in eels

Hiroshi Miyanishi, Shigenori Nobata, Yoshio Takei

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Atrial natriuretic peptide (ANP) exhibits a potent antidipsogenic effect in seawater (SW) eels to limit excess Na + uptake, thereby effectively promoting SW adaptation. Recently, cardiac ANP, BNP and VNP and brain CNP1, 3 and 4, have been identified in eels. We examined the antidipsogenic effect of all homologous NPs using conscious, cannulated eels in both FW and SW together with parameters that affect drinking. A dose-response study (0.011 nmol/kg) in SW eels showed the relative potency of the antidipsogenic effect was in the order ANP ≥ VNP > BNP = CNP3 > CNP1 ≥ CNP4, while the order was ANP = VNP = BNP > CNP3 = CNP1 = CNP4 for the vasodepressor effect. The minimum effective dose of ANP for the antidipsogenic effect is much lower than that in mammals. ANP, BNP and VNP at 0.3 nmol/kg decreased drinking, plasma Na + concentration and aortic pressure and increased hematocrit in SW eels. The cardiac NPs induced similar changes in drinking, aortic pressure and hematocrit in FW eels, but aside from BNP no change in plasma Na + concentration. CNPs had no effect on drinking, plasma Na + concentration and hematocrit but induced mild hypotension in both FW and SW eels, except for CNP3 that inhibited drinking in SW eels. These results show that ANP, BNP and VNP are potent antidipsogenic hormones in eels in spite of other regulatory factors working to induce drinking, and that CNPs are without effects on drinking except for the ancestor of the cardiac NPs, CNP3.

Original languageEnglish
Pages (from-to)719-726
Number of pages8
JournalZoological Science
Volume28
Issue number10
DOIs
Publication statusPublished - 2011 Oct
Externally publishedYes

Fingerprint

natriuretic peptides
eel
atrial natriuretic peptide
drinking
seawater
hematocrit
hypotension
dose response
ancestry
hormones
mammals
uptake mechanisms
brain

Keywords

  • blood pressure
  • drinking
  • hematocrit
  • natriuretic peptides
  • osmoregulation
  • plasma osmolality
  • teleost fish

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Relative antidipsogenic potencies of six homologous natriuretic peptides in eels. / Miyanishi, Hiroshi; Nobata, Shigenori; Takei, Yoshio.

In: Zoological Science, Vol. 28, No. 10, 10.2011, p. 719-726.

Research output: Contribution to journalArticle

Miyanishi, Hiroshi ; Nobata, Shigenori ; Takei, Yoshio. / Relative antidipsogenic potencies of six homologous natriuretic peptides in eels. In: Zoological Science. 2011 ; Vol. 28, No. 10. pp. 719-726.
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