Relative biological effectiveness of carbon ions for head-and-neck squamous cell carcinomas according to human papillomavirus status

Naoto Osu; Daijiro Kobayashi; Katsuyuki Shirai; Atsushi Musha; Hiro Sato; Yuka Hirota; Atsushi Shibata; Takahiro Oike; Tatsuya Ohno

doi:10.3390/jpm10030071

Relative biological effectiveness of carbon ions for head-and-neck squamous cell carcinomas according to human papillomavirus status

Naoto Osu, Daijiro Kobayashi, Katsuyuki Shirai, Atsushi Musha, Hiro Sato, Yuka Hirota, Atsushi Shibata, Takahiro Oike, Tatsuya Ohno

Research output: Contribution to journal › Article › peer-review

Abstract

Carbon-ion radiotherapy (CIRT) has strong antitumor effects and excellent dose conformity. In head-and-neck squamous cell carcinoma (HNSCC), human papillomavirus (HPV) status is a prognostic factor for photon radiotherapy outcomes. However, the effect of HPV status on the sensitivity of HNSCCs to carbon ions remains unclear. Here, we showed that the relative biological effectiveness (RBE) of carbon ions over X-rays was higher in HPV-negative cells than in HSGc-C5 cells, which are used for CIRT dose establishment, whereas the RBE in HPV-positive cells was modest. These data indicate that CIRT is more advantageous in HPV-negative than in HPVpositive HNSCCs.

Original language	English
Article number	71
Pages (from-to)	1-9
Number of pages	9
Journal	Journal of Personalized Medicine
Volume	10
Issue number	3
DOIs	https://doi.org/10.3390/jpm10030071
Publication status	Published - 2020 Sept
Externally published	Yes

Keywords

Carbon-ion radiotherapy
Head-and-neck tumors
Radiosensitivity
Relative biological effectiveness
Squamous cell carcinoma

ASJC Scopus subject areas

Medicine (miscellaneous)

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10.3390/jpm10030071

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title = "Relative biological effectiveness of carbon ions for head-and-neck squamous cell carcinomas according to human papillomavirus status",

abstract = "Carbon-ion radiotherapy (CIRT) has strong antitumor effects and excellent dose conformity. In head-and-neck squamous cell carcinoma (HNSCC), human papillomavirus (HPV) status is a prognostic factor for photon radiotherapy outcomes. However, the effect of HPV status on the sensitivity of HNSCCs to carbon ions remains unclear. Here, we showed that the relative biological effectiveness (RBE) of carbon ions over X-rays was higher in HPV-negative cells than in HSGc-C5 cells, which are used for CIRT dose establishment, whereas the RBE in HPV-positive cells was modest. These data indicate that CIRT is more advantageous in HPV-negative than in HPVpositive HNSCCs.",

keywords = "Carbon-ion radiotherapy, Head-and-neck tumors, Radiosensitivity, Relative biological effectiveness, Squamous cell carcinoma",

author = "Naoto Osu and Daijiro Kobayashi and Katsuyuki Shirai and Atsushi Musha and Hiro Sato and Yuka Hirota and Atsushi Shibata and Takahiro Oike and Tatsuya Ohno",

note = "Funding Information: Funding: This work was supported by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science, and Technology of Japan for programs for Leading Graduate Schools, Cultivating Global Leaders in Heavy Ion Therapeutics and Engineering. This work was also supported by the Gunma University Heavy Ion Medical Center. Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2020",

month = sep,

doi = "10.3390/jpm10030071",

language = "English",

volume = "10",

pages = "1--9",

journal = "Journal of Personalized Medicine",

issn = "2075-4426",

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TY - JOUR

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AU - Osu, Naoto

AU - Kobayashi, Daijiro

AU - Shirai, Katsuyuki

AU - Musha, Atsushi

AU - Sato, Hiro

AU - Hirota, Yuka

AU - Shibata, Atsushi

AU - Oike, Takahiro

AU - Ohno, Tatsuya

N1 - Funding Information: Funding: This work was supported by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science, and Technology of Japan for programs for Leading Graduate Schools, Cultivating Global Leaders in Heavy Ion Therapeutics and Engineering. This work was also supported by the Gunma University Heavy Ion Medical Center. Publisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2020/9

Y1 - 2020/9

N2 - Carbon-ion radiotherapy (CIRT) has strong antitumor effects and excellent dose conformity. In head-and-neck squamous cell carcinoma (HNSCC), human papillomavirus (HPV) status is a prognostic factor for photon radiotherapy outcomes. However, the effect of HPV status on the sensitivity of HNSCCs to carbon ions remains unclear. Here, we showed that the relative biological effectiveness (RBE) of carbon ions over X-rays was higher in HPV-negative cells than in HSGc-C5 cells, which are used for CIRT dose establishment, whereas the RBE in HPV-positive cells was modest. These data indicate that CIRT is more advantageous in HPV-negative than in HPVpositive HNSCCs.

AB - Carbon-ion radiotherapy (CIRT) has strong antitumor effects and excellent dose conformity. In head-and-neck squamous cell carcinoma (HNSCC), human papillomavirus (HPV) status is a prognostic factor for photon radiotherapy outcomes. However, the effect of HPV status on the sensitivity of HNSCCs to carbon ions remains unclear. Here, we showed that the relative biological effectiveness (RBE) of carbon ions over X-rays was higher in HPV-negative cells than in HSGc-C5 cells, which are used for CIRT dose establishment, whereas the RBE in HPV-positive cells was modest. These data indicate that CIRT is more advantageous in HPV-negative than in HPVpositive HNSCCs.

KW - Carbon-ion radiotherapy

KW - Head-and-neck tumors

KW - Radiosensitivity

KW - Relative biological effectiveness

KW - Squamous cell carcinoma

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Relative biological effectiveness of carbon ions for head-and-neck squamous cell carcinomas according to human papillomavirus status

Abstract

Keywords

ASJC Scopus subject areas

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