Relaxin and myometrial activity

Takuro Osa, Hiroyoshi Inoue, Koji Okabe

Research output: Contribution to journalArticle

Abstract

The research on intracellular signal transduction and the smooth muscle contraction have made much progress since 1970. Effects of relaxin, a peptide hormone mainly produced and released from ovary, are reviewed in the above point of view. Cyclic AMP content in myometrial cells is increased by relaxin. One site of relaxin action can be the suppression of myosin light chain kinase activity. Another effect of relaxin is the suppression of action potential, whereby the Ca-influx is reduced. However, relaxin up to 300 mU does not hyperpolarize the myometrial membrane of estrogen-primed rat, which differs from the adrenergic β-action. Unrealed signal transduction seems involved in the relaxin action.

Original languageEnglish
Pages (from-to)67-74
Number of pages8
JournalJournal of Smooth Muscle Research
Volume27
Issue number1
DOIs
Publication statusPublished - 1991 Jan 1
Externally publishedYes

Fingerprint

Relaxin
Signal Transduction
Myosin-Light-Chain Kinase
Peptide Hormones
Muscle Contraction
Cyclic AMP
Adrenergic Agents
Action Potentials
Smooth Muscle
Ovary
Estrogens
Membranes
Research

ASJC Scopus subject areas

  • Physiology

Cite this

Relaxin and myometrial activity. / Osa, Takuro; Inoue, Hiroyoshi; Okabe, Koji.

In: Journal of Smooth Muscle Research, Vol. 27, No. 1, 01.01.1991, p. 67-74.

Research output: Contribution to journalArticle

Osa, Takuro ; Inoue, Hiroyoshi ; Okabe, Koji. / Relaxin and myometrial activity. In: Journal of Smooth Muscle Research. 1991 ; Vol. 27, No. 1. pp. 67-74.
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