Release of band cells from the bone marrow is impaired by preoperative chemoradiation in patients with esophageal carcinoma: Increased risk of postoperative pneumonia

Tatsushi Suwa, Yuukou Kitagawa, Takahiro Sasaki, Tomoo Shatari, Masayoshi Sakuma, Masaki Kitajima

Research output: Contribution to journalArticle

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Abstract

Purpose: To examine the difference in hematological data and postsurgical course after esophagectomy between patients receiving preoperative chemoradiation and patients without preoperative treatment. Methods: Twenty-two patients with squamous cell carcinoma of the esophagus who underwent esophagectomy during the past 2 years were retrospectively analyzed in the study. Six patients had preoperative chemoradiation (CRT group) and 16 patients had no preoperative treatment (non-CRT group). The hematological data, postoperative course, and surgical complications were compared between the two groups. Results: Patients in the CRT group were given cisplatin and 5-FU (143 and 6,000 mg on average, respectively) plus an average of 35 Gy of radiation. Although the neutrophil count did not show a significant difference between the two groups, the band cell count was lower in the CRT group compared with the non-CRT group on postoperative day 1 (P<0.05). Postoperative pneumonia was detected in three patients (50%) from the CRT group versus none of the non-CRT group. Conclusion: Preoperative CRT may be a risk factor for postoperative pneumonia in patients with esophageal carcinoma who undergo esophagectomy. The normal bone marrow response of releasing band cells from the postmitotic marrow pool after surgery could be disturbed by CRT, which might contribute to an increase in later pulmonary complications.

Original languageEnglish
Pages (from-to)461-466
Number of pages6
JournalLangenbeck's Archives of Surgery
Volume391
Issue number5
DOIs
Publication statusPublished - 2006 Sep

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Bone Marrow Cells
Pneumonia
Carcinoma
Esophagectomy
Bone Marrow
Radiation Dosage
Fluorouracil
Cisplatin
Esophagus
Squamous Cell Carcinoma
Neutrophils
Cell Count
Lung
Therapeutics

Keywords

  • Band cell
  • Bone marrow
  • Chemoradiation
  • Esophageal carcinoma
  • Neutrophil

ASJC Scopus subject areas

  • Surgery

Cite this

Release of band cells from the bone marrow is impaired by preoperative chemoradiation in patients with esophageal carcinoma : Increased risk of postoperative pneumonia. / Suwa, Tatsushi; Kitagawa, Yuukou; Sasaki, Takahiro; Shatari, Tomoo; Sakuma, Masayoshi; Kitajima, Masaki.

In: Langenbeck's Archives of Surgery, Vol. 391, No. 5, 09.2006, p. 461-466.

Research output: Contribution to journalArticle

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