Relief of vasospasm by intravascular ultraviolet irradiation

Kanji Nakai, Yuji Morimoto, Hirotaka Ito, Kimito Kominami, Hirotaka Matsuo, Tsunenori Arai, Makoto Kikuchi

Research output: Contribution to journalConference articlepeer-review


We investigated the photovasorelaxation with intravascular transluminal irradiation using in vivo model. A 2.5 Fr. catheter was inserted in the femoral artery of a rabbit under anesthesia. A 400 μ m diameter quartz fiber was inserted through the catheter. The catheter was withdrawn from the distal end to the proximal end of the exposed femoral artery without laser irradiation in order to observe the mechanical dilation by the procedure. The femoral artery lumen was inadiated by a Helium-Cadmium(He-Cd) laser (wave length; 325 nm) with 8 mW through the fiber during 30 s. We carried out that the laser irradiation produced vasorelaxation (185% on the average) compared with mechanical vasodilation (150% on the average) with angiography. The results suggest that intravascular transluminal irradiation with low-power UV laser might be applicable to the relief of acute arterial vasospasm.

Original languageEnglish
Pages (from-to)42-45
Number of pages4
JournalProceedings of SPIE - The International Society for Optical Engineering
Publication statusPublished - 1998 Dec 1
EventLaser-Tissue Interaction IX - San Jose, CA, United States
Duration: 1998 Jan 261998 Jan 28


  • Femoral artery
  • Helium-Cadmium laser
  • Laser irradiation
  • Nitric oxide
  • Photorelaxation
  • Rabbit

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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