Relief of vasospasm by intravascular ultraviolet irradiation

Kanji Nakai, Yuji Morimoto, Hirotaka Ito, Kimito Kominami, Hirotaka Matsuo, Tsunenori Arai, Makoto Kikuchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution


We investigated the photovasorelaxation with intravascular transluminal irradiation using in vivo model. A 2.5 Fr. catheter was inserted in the femoral artery of a rabbit under anesthesia. A 400 μ m diameter quartz fiber was inserted through the catheter. The catheter was withdrawn from the distal end to the proximal end of the exposed femoral artery without laser irradiation in order to observe the mechanical dilation by the procedure. The femoral artery lumen was inadiated by a Helium-Cadmium(He-Cd) laser (wave length; 325 nm) with 8 mW through the fiber during 30 s. We carried out that the laser irradiation produced vasorelaxation (185% on the average) compared with mechanical vasodilation (150% on the average) with angiography. The results suggest that intravascular transluminal irradiation with low-power UV laser might be applicable to the relief of acute arterial vasospasm.

Original languageEnglish
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsS.L. Jacques
Number of pages4
Publication statusPublished - 1998
Externally publishedYes
EventLaser-Tissue Interaction IX - San Jose, CA, United States
Duration: 1998 Jan 261998 Jan 28


OtherLaser-Tissue Interaction IX
CountryUnited States
CitySan Jose, CA



  • Femoral artery
  • Helium-Cadmium laser
  • Laser irradiation
  • Nitric oxide
  • Photorelaxation
  • Rabbit

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Nakai, K., Morimoto, Y., Ito, H., Kominami, K., Matsuo, H., Arai, T., & Kikuchi, M. (1998). Relief of vasospasm by intravascular ultraviolet irradiation. In S. L. Jacques (Ed.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3254, pp. 42-45)