Remission of Angiographically Confirmed Minocycline-induced Renal Polyarteritis Nodosa: A Case Report and Literature Review

Kenichi Yokota, Isao Kurihara, Toshifumi Nakamura, Seishi Nakatsuka, Kazutoshi Miyashita, Sakiko Kobayashi, Ayano Murai-Takeda, Masakatsu Sone, Hiroshi Itoh

Research output: Contribution to journalReview articlepeer-review

Abstract

A 23-year-old man presented with severe hypertension. Based on his history of minocycline treatment for over three years and clinical symptoms, such as myalgias and renovascular hypertension with multiple intrarenal aneurysms, he was diagnosed with minocycline-induced renal polyarteritis nodosa (PAN). After minocycline treatment cessation and management of the hypertension, his blood pressure, renin-aldosterone levels, and urinary protein levels gradually improved. Seven and a half years later, repeated angiography found that the aneurysms had resolved. This is the first report in English describing a case of minocycline-induced renal PAN that was reversed functionally and morphologically without steroids or immunosuppressive drugs.

Original languageEnglish
Pages (from-to)103-110
Number of pages8
JournalInternal Medicine
Volume61
Issue number1
DOIs
Publication statusPublished - 2022

Keywords

  • Aneurysms
  • Angiography
  • Drug-induced vasculitis
  • Minocycline
  • Polyarteritis nodosa
  • Renovascular hypertension

ASJC Scopus subject areas

  • Internal Medicine

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