Remission of Angiographically Confirmed Minocycline-induced Renal Polyarteritis Nodosa: A Case Report and Literature Review

Kenichi Yokota; Isao Kurihara; Toshifumi Nakamura; Seishi Nakatsuka; Kazutoshi Miyashita; Sakiko Kobayashi; Ayano Murai-Takeda; Masakatsu Sone; Hiroshi Itoh

doi:10.2169/internalmedicine.7340-21

Remission of Angiographically Confirmed Minocycline-induced Renal Polyarteritis Nodosa: A Case Report and Literature Review

Kenichi Yokota, Isao Kurihara, Toshifumi Nakamura, Seishi Nakatsuka, Kazutoshi Miyashita, Sakiko Kobayashi, Ayano Murai-Takeda, Masakatsu Sone, Hiroshi Itoh

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

A 23-year-old man presented with severe hypertension. Based on his history of minocycline treatment for over three years and clinical symptoms, such as myalgias and renovascular hypertension with multiple intrarenal aneurysms, he was diagnosed with minocycline-induced renal polyarteritis nodosa (PAN). After minocycline treatment cessation and management of the hypertension, his blood pressure, renin-aldosterone levels, and urinary protein levels gradually improved. Seven and a half years later, repeated angiography found that the aneurysms had resolved. This is the first report in English describing a case of minocycline-induced renal PAN that was reversed functionally and morphologically without steroids or immunosuppressive drugs.

Original language	English
Pages (from-to)	103-110
Number of pages	8
Journal	Internal Medicine
Volume	61
Issue number	1
DOIs	https://doi.org/10.2169/internalmedicine.7340-21
Publication status	Published - 2022

Keywords

Aneurysms
Angiography
Drug-induced vasculitis
Minocycline
Polyarteritis nodosa
Renovascular hypertension

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.7340-21

Cite this

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title = "Remission of Angiographically Confirmed Minocycline-induced Renal Polyarteritis Nodosa: A Case Report and Literature Review",

abstract = "A 23-year-old man presented with severe hypertension. Based on his history of minocycline treatment for over three years and clinical symptoms, such as myalgias and renovascular hypertension with multiple intrarenal aneurysms, he was diagnosed with minocycline-induced renal polyarteritis nodosa (PAN). After minocycline treatment cessation and management of the hypertension, his blood pressure, renin-aldosterone levels, and urinary protein levels gradually improved. Seven and a half years later, repeated angiography found that the aneurysms had resolved. This is the first report in English describing a case of minocycline-induced renal PAN that was reversed functionally and morphologically without steroids or immunosuppressive drugs.",

keywords = "Aneurysms, Angiography, Drug-induced vasculitis, Minocycline, Polyarteritis nodosa, Renovascular hypertension",

author = "Kenichi Yokota and Isao Kurihara and Toshifumi Nakamura and Seishi Nakatsuka and Kazutoshi Miyashita and Sakiko Kobayashi and Ayano Murai-Takeda and Masakatsu Sone and Hiroshi Itoh",

year = "2022",

doi = "10.2169/internalmedicine.7340-21",

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T1 - Remission of Angiographically Confirmed Minocycline-induced Renal Polyarteritis Nodosa

T2 - A Case Report and Literature Review

AU - Yokota, Kenichi

AU - Kurihara, Isao

AU - Nakamura, Toshifumi

AU - Nakatsuka, Seishi

AU - Miyashita, Kazutoshi

AU - Kobayashi, Sakiko

AU - Murai-Takeda, Ayano

AU - Sone, Masakatsu

AU - Itoh, Hiroshi

PY - 2022

Y1 - 2022

N2 - A 23-year-old man presented with severe hypertension. Based on his history of minocycline treatment for over three years and clinical symptoms, such as myalgias and renovascular hypertension with multiple intrarenal aneurysms, he was diagnosed with minocycline-induced renal polyarteritis nodosa (PAN). After minocycline treatment cessation and management of the hypertension, his blood pressure, renin-aldosterone levels, and urinary protein levels gradually improved. Seven and a half years later, repeated angiography found that the aneurysms had resolved. This is the first report in English describing a case of minocycline-induced renal PAN that was reversed functionally and morphologically without steroids or immunosuppressive drugs.

AB - A 23-year-old man presented with severe hypertension. Based on his history of minocycline treatment for over three years and clinical symptoms, such as myalgias and renovascular hypertension with multiple intrarenal aneurysms, he was diagnosed with minocycline-induced renal polyarteritis nodosa (PAN). After minocycline treatment cessation and management of the hypertension, his blood pressure, renin-aldosterone levels, and urinary protein levels gradually improved. Seven and a half years later, repeated angiography found that the aneurysms had resolved. This is the first report in English describing a case of minocycline-induced renal PAN that was reversed functionally and morphologically without steroids or immunosuppressive drugs.

KW - Aneurysms

KW - Angiography

KW - Drug-induced vasculitis

KW - Minocycline

KW - Polyarteritis nodosa

KW - Renovascular hypertension

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DO - 10.2169/internalmedicine.7340-21

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Remission of Angiographically Confirmed Minocycline-induced Renal Polyarteritis Nodosa: A Case Report and Literature Review

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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