Renal cell carcinoma: Biological features and rationale for molecular-targeted therapy

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Cancer cells are characterized by indefinite proliferation, invasiveness and metastases. These characteristics are usually related to one another. Namely, cancer cells that proliferate rapidly tend to invade and metastasize. Renal cell carcinoma (RCC) typically does not proliferate rapidly nor does it invade the surrounding tissues, but it does metastasize. RCC has several peculiar characteristics that are not observed in other cancers: a relatively late recurrence, a high frequency of paraneoplastic syndrome, hypervascularity and the spontaneous regression of metastatic lesions after the excision of the primary tumor. These clinical observations suggest that cytokines or growth factors are important contributors to microenvironments favoring the growth of cancer cells. Thus, the blockade of cell-to-cell communication might have some therapeutic potential. Accordingly, a popular strategy for molecular-targeted therapy for RCC targets the vasculization of RCC induced by vascular endothelial growth factor (VEGF). This review highlights the biological features of RCC that are relevant to molecular-targeted therapy.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalKeio Journal of Medicine
Volume58
Issue number1
DOIs
Publication statusPublished - 2009 Mar

Fingerprint

Molecular Targeted Therapy
Renal Cell Carcinoma
Neoplasms
Paraneoplastic Syndromes
Cell Communication
Vascular Endothelial Growth Factor A
Intercellular Signaling Peptides and Proteins
Cytokines
Neoplasm Metastasis
Recurrence
Growth

Keywords

  • Cytokine
  • Molecular-targeted therapy
  • Renal cell carcinoma
  • Vascular endothelial growth factor (VEGF)

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Renal cell carcinoma : Biological features and rationale for molecular-targeted therapy. / Oya, Mototsugu.

In: Keio Journal of Medicine, Vol. 58, No. 1, 03.2009, p. 1-11.

Research output: Contribution to journalArticle

@article{8da676700fde4bab97a233b7d43ff9e0,
title = "Renal cell carcinoma: Biological features and rationale for molecular-targeted therapy",
abstract = "Cancer cells are characterized by indefinite proliferation, invasiveness and metastases. These characteristics are usually related to one another. Namely, cancer cells that proliferate rapidly tend to invade and metastasize. Renal cell carcinoma (RCC) typically does not proliferate rapidly nor does it invade the surrounding tissues, but it does metastasize. RCC has several peculiar characteristics that are not observed in other cancers: a relatively late recurrence, a high frequency of paraneoplastic syndrome, hypervascularity and the spontaneous regression of metastatic lesions after the excision of the primary tumor. These clinical observations suggest that cytokines or growth factors are important contributors to microenvironments favoring the growth of cancer cells. Thus, the blockade of cell-to-cell communication might have some therapeutic potential. Accordingly, a popular strategy for molecular-targeted therapy for RCC targets the vasculization of RCC induced by vascular endothelial growth factor (VEGF). This review highlights the biological features of RCC that are relevant to molecular-targeted therapy.",
keywords = "Cytokine, Molecular-targeted therapy, Renal cell carcinoma, Vascular endothelial growth factor (VEGF)",
author = "Mototsugu Oya",
year = "2009",
month = "3",
doi = "10.2302/kjm.58.1",
language = "English",
volume = "58",
pages = "1--11",
journal = "Keio Journal of Medicine",
issn = "0022-9717",
publisher = "Keio University School of Medicine",
number = "1",

}

TY - JOUR

T1 - Renal cell carcinoma

T2 - Biological features and rationale for molecular-targeted therapy

AU - Oya, Mototsugu

PY - 2009/3

Y1 - 2009/3

N2 - Cancer cells are characterized by indefinite proliferation, invasiveness and metastases. These characteristics are usually related to one another. Namely, cancer cells that proliferate rapidly tend to invade and metastasize. Renal cell carcinoma (RCC) typically does not proliferate rapidly nor does it invade the surrounding tissues, but it does metastasize. RCC has several peculiar characteristics that are not observed in other cancers: a relatively late recurrence, a high frequency of paraneoplastic syndrome, hypervascularity and the spontaneous regression of metastatic lesions after the excision of the primary tumor. These clinical observations suggest that cytokines or growth factors are important contributors to microenvironments favoring the growth of cancer cells. Thus, the blockade of cell-to-cell communication might have some therapeutic potential. Accordingly, a popular strategy for molecular-targeted therapy for RCC targets the vasculization of RCC induced by vascular endothelial growth factor (VEGF). This review highlights the biological features of RCC that are relevant to molecular-targeted therapy.

AB - Cancer cells are characterized by indefinite proliferation, invasiveness and metastases. These characteristics are usually related to one another. Namely, cancer cells that proliferate rapidly tend to invade and metastasize. Renal cell carcinoma (RCC) typically does not proliferate rapidly nor does it invade the surrounding tissues, but it does metastasize. RCC has several peculiar characteristics that are not observed in other cancers: a relatively late recurrence, a high frequency of paraneoplastic syndrome, hypervascularity and the spontaneous regression of metastatic lesions after the excision of the primary tumor. These clinical observations suggest that cytokines or growth factors are important contributors to microenvironments favoring the growth of cancer cells. Thus, the blockade of cell-to-cell communication might have some therapeutic potential. Accordingly, a popular strategy for molecular-targeted therapy for RCC targets the vasculization of RCC induced by vascular endothelial growth factor (VEGF). This review highlights the biological features of RCC that are relevant to molecular-targeted therapy.

KW - Cytokine

KW - Molecular-targeted therapy

KW - Renal cell carcinoma

KW - Vascular endothelial growth factor (VEGF)

UR - http://www.scopus.com/inward/record.url?scp=65949104573&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65949104573&partnerID=8YFLogxK

U2 - 10.2302/kjm.58.1

DO - 10.2302/kjm.58.1

M3 - Article

C2 - 19398878

AN - SCOPUS:65949104573

VL - 58

SP - 1

EP - 11

JO - Keio Journal of Medicine

JF - Keio Journal of Medicine

SN - 0022-9717

IS - 1

ER -