Renal function-based contrast dosing predicts acute kidney injury following transcatheter aortic valve implantation

Masanori Yamamoto, Kentaro Hayashida, Gauthier Mouillet, Bernard Chevalier, Kentaro Meguro, Yusuke Watanabe, Jean Luc Dubois-Rande, Marie Claude Morice, Thierry Lefèvre, Emmanuel Teiger

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Abstract

Objectives: This study sought to assess whether the volume of contrast media (CM) influences the occurrence of acute kidney injury (AKI) following transcatheter aortic valve implantation (TAVI). Background: The volume of CM has been shown to be associated with increasing risk of AKI; however, in a high-risk elderly TAVI population, the predictive value and optimal threshold of CM dose on AKI remain uncertain. Methods: Data of 415 consecutive transfemoral TAVI patients (age 83.6 ± 6.8 years, logistic EuroSCORE 23.0 ± 12.2%) were analyzed. AKI was defined by Valve Academic Research Consortium criteria. Based on a previous formula, the ratio of CM to serum creatinine (SCr) and body weight (BW) (CM × SCr/BW) was calculated as defining the degree of CM use. The association between CM dose and incidence of AKI, as well as predictive factors and prognosis of AKI, were investigated. Results: AKI occurred in 63 patients (15.2%). Cumulative 1-year mortality showed significant differences between the AKI and non-AKI groups (47.9% vs. 15.7%, p < 0.001). Mean CM × SCr/BW ratio was higher in the AKI group than in the non-AKI group (4.1 ± 2.9 vs. 2.9 ± 1.6, p < 0.001). By multivariate analysis, CM × SCr/BW per 1.0 increase, ejection fraction <40%, and transfusion were associated with the occurrence of AKI (odds ratio [OR]: 1.16; 95% confidence interval [CI]: 1.03 to 1.20; p = 0.017, OR: 3.01; 95% CI: 1.49 to 5.00; p = 0.001, OR: 2.73; 95% CI: 1.54 to 6.15; p = 0.001, respectively). A threshold value of CM × SCr/BW for predicting AKI was statistically identified as 2.7. Conclusions: Although mechanisms of AKI following TAVI are multifactorial, the present study identified a relationship between CM dose increment and high prevalence of AKI. Therapeutic efforts not to exceed the threshold value may reduce the risk of AKI.

Original languageEnglish
Pages (from-to)479-486
Number of pages8
JournalJACC: Cardiovascular Interventions
Volume6
Issue number5
DOIs
Publication statusPublished - 2013 May
Externally publishedYes

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Acute Kidney Injury
Contrast Media
Kidney
Creatinine
Body Weight
Serum
Odds Ratio
Confidence Intervals
Transcatheter Aortic Valve Replacement
Wounds and Injuries
Multivariate Analysis

Keywords

  • acute kidney injury
  • contrast media
  • transcatheter aortic valve implantation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Renal function-based contrast dosing predicts acute kidney injury following transcatheter aortic valve implantation. / Yamamoto, Masanori; Hayashida, Kentaro; Mouillet, Gauthier; Chevalier, Bernard; Meguro, Kentaro; Watanabe, Yusuke; Dubois-Rande, Jean Luc; Morice, Marie Claude; Lefèvre, Thierry; Teiger, Emmanuel.

In: JACC: Cardiovascular Interventions, Vol. 6, No. 5, 05.2013, p. 479-486.

Research output: Contribution to journalArticle

Yamamoto, M, Hayashida, K, Mouillet, G, Chevalier, B, Meguro, K, Watanabe, Y, Dubois-Rande, JL, Morice, MC, Lefèvre, T & Teiger, E 2013, 'Renal function-based contrast dosing predicts acute kidney injury following transcatheter aortic valve implantation', JACC: Cardiovascular Interventions, vol. 6, no. 5, pp. 479-486. https://doi.org/10.1016/j.jcin.2013.02.007
Yamamoto, Masanori ; Hayashida, Kentaro ; Mouillet, Gauthier ; Chevalier, Bernard ; Meguro, Kentaro ; Watanabe, Yusuke ; Dubois-Rande, Jean Luc ; Morice, Marie Claude ; Lefèvre, Thierry ; Teiger, Emmanuel. / Renal function-based contrast dosing predicts acute kidney injury following transcatheter aortic valve implantation. In: JACC: Cardiovascular Interventions. 2013 ; Vol. 6, No. 5. pp. 479-486.
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title = "Renal function-based contrast dosing predicts acute kidney injury following transcatheter aortic valve implantation",
abstract = "Objectives: This study sought to assess whether the volume of contrast media (CM) influences the occurrence of acute kidney injury (AKI) following transcatheter aortic valve implantation (TAVI). Background: The volume of CM has been shown to be associated with increasing risk of AKI; however, in a high-risk elderly TAVI population, the predictive value and optimal threshold of CM dose on AKI remain uncertain. Methods: Data of 415 consecutive transfemoral TAVI patients (age 83.6 ± 6.8 years, logistic EuroSCORE 23.0 ± 12.2{\%}) were analyzed. AKI was defined by Valve Academic Research Consortium criteria. Based on a previous formula, the ratio of CM to serum creatinine (SCr) and body weight (BW) (CM × SCr/BW) was calculated as defining the degree of CM use. The association between CM dose and incidence of AKI, as well as predictive factors and prognosis of AKI, were investigated. Results: AKI occurred in 63 patients (15.2{\%}). Cumulative 1-year mortality showed significant differences between the AKI and non-AKI groups (47.9{\%} vs. 15.7{\%}, p < 0.001). Mean CM × SCr/BW ratio was higher in the AKI group than in the non-AKI group (4.1 ± 2.9 vs. 2.9 ± 1.6, p < 0.001). By multivariate analysis, CM × SCr/BW per 1.0 increase, ejection fraction <40{\%}, and transfusion were associated with the occurrence of AKI (odds ratio [OR]: 1.16; 95{\%} confidence interval [CI]: 1.03 to 1.20; p = 0.017, OR: 3.01; 95{\%} CI: 1.49 to 5.00; p = 0.001, OR: 2.73; 95{\%} CI: 1.54 to 6.15; p = 0.001, respectively). A threshold value of CM × SCr/BW for predicting AKI was statistically identified as 2.7. Conclusions: Although mechanisms of AKI following TAVI are multifactorial, the present study identified a relationship between CM dose increment and high prevalence of AKI. Therapeutic efforts not to exceed the threshold value may reduce the risk of AKI.",
keywords = "acute kidney injury, contrast media, transcatheter aortic valve implantation",
author = "Masanori Yamamoto and Kentaro Hayashida and Gauthier Mouillet and Bernard Chevalier and Kentaro Meguro and Yusuke Watanabe and Dubois-Rande, {Jean Luc} and Morice, {Marie Claude} and Thierry Lef{\`e}vre and Emmanuel Teiger",
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AU - Hayashida, Kentaro

AU - Mouillet, Gauthier

AU - Chevalier, Bernard

AU - Meguro, Kentaro

AU - Watanabe, Yusuke

AU - Dubois-Rande, Jean Luc

AU - Morice, Marie Claude

AU - Lefèvre, Thierry

AU - Teiger, Emmanuel

PY - 2013/5

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N2 - Objectives: This study sought to assess whether the volume of contrast media (CM) influences the occurrence of acute kidney injury (AKI) following transcatheter aortic valve implantation (TAVI). Background: The volume of CM has been shown to be associated with increasing risk of AKI; however, in a high-risk elderly TAVI population, the predictive value and optimal threshold of CM dose on AKI remain uncertain. Methods: Data of 415 consecutive transfemoral TAVI patients (age 83.6 ± 6.8 years, logistic EuroSCORE 23.0 ± 12.2%) were analyzed. AKI was defined by Valve Academic Research Consortium criteria. Based on a previous formula, the ratio of CM to serum creatinine (SCr) and body weight (BW) (CM × SCr/BW) was calculated as defining the degree of CM use. The association between CM dose and incidence of AKI, as well as predictive factors and prognosis of AKI, were investigated. Results: AKI occurred in 63 patients (15.2%). Cumulative 1-year mortality showed significant differences between the AKI and non-AKI groups (47.9% vs. 15.7%, p < 0.001). Mean CM × SCr/BW ratio was higher in the AKI group than in the non-AKI group (4.1 ± 2.9 vs. 2.9 ± 1.6, p < 0.001). By multivariate analysis, CM × SCr/BW per 1.0 increase, ejection fraction <40%, and transfusion were associated with the occurrence of AKI (odds ratio [OR]: 1.16; 95% confidence interval [CI]: 1.03 to 1.20; p = 0.017, OR: 3.01; 95% CI: 1.49 to 5.00; p = 0.001, OR: 2.73; 95% CI: 1.54 to 6.15; p = 0.001, respectively). A threshold value of CM × SCr/BW for predicting AKI was statistically identified as 2.7. Conclusions: Although mechanisms of AKI following TAVI are multifactorial, the present study identified a relationship between CM dose increment and high prevalence of AKI. Therapeutic efforts not to exceed the threshold value may reduce the risk of AKI.

AB - Objectives: This study sought to assess whether the volume of contrast media (CM) influences the occurrence of acute kidney injury (AKI) following transcatheter aortic valve implantation (TAVI). Background: The volume of CM has been shown to be associated with increasing risk of AKI; however, in a high-risk elderly TAVI population, the predictive value and optimal threshold of CM dose on AKI remain uncertain. Methods: Data of 415 consecutive transfemoral TAVI patients (age 83.6 ± 6.8 years, logistic EuroSCORE 23.0 ± 12.2%) were analyzed. AKI was defined by Valve Academic Research Consortium criteria. Based on a previous formula, the ratio of CM to serum creatinine (SCr) and body weight (BW) (CM × SCr/BW) was calculated as defining the degree of CM use. The association between CM dose and incidence of AKI, as well as predictive factors and prognosis of AKI, were investigated. Results: AKI occurred in 63 patients (15.2%). Cumulative 1-year mortality showed significant differences between the AKI and non-AKI groups (47.9% vs. 15.7%, p < 0.001). Mean CM × SCr/BW ratio was higher in the AKI group than in the non-AKI group (4.1 ± 2.9 vs. 2.9 ± 1.6, p < 0.001). By multivariate analysis, CM × SCr/BW per 1.0 increase, ejection fraction <40%, and transfusion were associated with the occurrence of AKI (odds ratio [OR]: 1.16; 95% confidence interval [CI]: 1.03 to 1.20; p = 0.017, OR: 3.01; 95% CI: 1.49 to 5.00; p = 0.001, OR: 2.73; 95% CI: 1.54 to 6.15; p = 0.001, respectively). A threshold value of CM × SCr/BW for predicting AKI was statistically identified as 2.7. Conclusions: Although mechanisms of AKI following TAVI are multifactorial, the present study identified a relationship between CM dose increment and high prevalence of AKI. Therapeutic efforts not to exceed the threshold value may reduce the risk of AKI.

KW - acute kidney injury

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