Renal protective effects of efonidipine in partially nephrectomized spontaneously hypertensive rats

Keiji Fujiwara, Yoshihiko Kanno, Koichi Hayashi, Tsuneo Takenaka, Takao Saruta

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Abstract

We investigated the effects of a calcium antagonist, efonidipine, which was reported to dilate not only afferent arterioles but also efferent arterioles, on progression of renal failure in salt-loaded partially nephrectomized spontaneously hypertensive rats (SHR). Forty-four SHR's with 5 of 6 nephrectomy were divided into four groups: group I as control (n=20); group 2, efonidipine-treated (n=8); group 3, enalapril-treated (n=8); and group 4, nifedipine-treated (n=8). The rats were given these drugs and a high-salt diet (5% NaCl) for 8 weeks. During the experiment, systolic blood pressure (SBP) and daily urinary, protein excretion were measured every 2 weeks. At the end of the study, serum creatinine was determined, and renal tissues were obtained for light microscopic examination. SBP was markedly reduced by 8-week antihypertensive treatment. (control, 267±7 mmHg; efonidipine, 181±7 mmHg; enalapril, 200±12 mmHg; nifedipine, 184±6 mmHg). Glomerular sclerosis developed markedly in the control group, but was partially prevented in all treated groups. Similarly, urinary protein excretion (UPE) was suppressed by efonidipine (180±16 mg/day) and enalapril (186±16 mg/day vs. 301±28 mg/day for control). In contrast, nifedipine failed to prevent the increase in urinary protein excretion (258±22 mg/day). In conclusion, efonidipine attenuates SBP increase and ameliorates glomerular injury as well as nifedipine and enalapril. Furthermore, beneficial effects of efonidipine, but not nifedipine, on proteinuria suggest that different mechanisms mediate the improvement of proteinuria; one possible mechanism could be efferent arteriolar dilation, not reported in nifedipine.

Original languageEnglish
Pages (from-to)295-312
Number of pages18
JournalClinical and Experimental Hypertension
Volume20
Issue number3
DOIs
Publication statusPublished - 1998 Apr

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Keywords

  • Calcium antagonists
  • Efonidipine
  • Enalapril
  • Glomerular injury
  • Hypertension
  • Nifedipine

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

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