Renin-angiotensin system hyperactivation can induce inflammation and retinal neural dysfunction

Toshihide Kurihara, Yoko Ozawa, Susumu Ishida, Hideyuki Okano, Kazuo Tsubota

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The renin-angiotensin system (RAS) is a hormone system that has been classically known as a blood pressure regulator but is becoming well recognized as a proinflammatory mediator. In many diverse tissues, RAS pathway elements are also produced intrinsically, making it possible for tissues to respond more dynamically to systemic or local cues. While RAS is important for controlling normal inflammatory responses, hyperactivation of the pathway can cause neural dysfunction by inducing accelerated degradation of some neuronal proteins such as synaptophysin and by activating pathological glial responses. Chronic inflammation and oxidative stress are risk factors for high incidence vision-threatening diseases such as diabetic retinopathy (DR), age-related macular degeneration (AMD), and glaucoma. In fact, increasing evidence suggests that RAS inhibition may actually prevent progression of various ocular diseases including uveitis, DR, AMD, and glaucoma. Therefore, RAS inhibition may be a promising therapeutic approach to fine-tune inflammatory responses and to prevent or treat certain ocular and neurodegenerative diseases.

Original languageEnglish
Article number581695
JournalInternational Journal of Inflammation
Volume2012
DOIs
Publication statusPublished - 2012

Fingerprint

Renin-Angiotensin System
Inflammation
Eye Diseases
Macular Degeneration
Diabetic Retinopathy
Glaucoma
Synaptophysin
Uveitis
Neuroglia
Neurodegenerative Diseases
Cues
Oxidative Stress
Hormones
Blood Pressure
Incidence
Proteins
Inhibition (Psychology)
Therapeutics

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Renin-angiotensin system hyperactivation can induce inflammation and retinal neural dysfunction. / Kurihara, Toshihide; Ozawa, Yoko; Ishida, Susumu; Okano, Hideyuki; Tsubota, Kazuo.

In: International Journal of Inflammation, Vol. 2012, 581695, 2012.

Research output: Contribution to journalArticle

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