Reoxygenation in tumor tissues after X-ray or carbon-12 irradiation

Takeshi Fukawa; Koji Takematsu; Kotaro Oka; Nobuyuki Miyahara; Sachiko Koike; Koichi Ando; Hirosuke Kobayashi; Kazuo Tanishita

Reoxygenation in tumor tissues after X-ray or carbon-12 irradiation

Takeshi Fukawa, Koji Takematsu, Kotaro Oka, Nobuyuki Miyahara, Sachiko Koike, Koichi Ando, Hirosuke Kobayashi, Kazuo Tanishita

Department of Biosciences and Informatics

Research output: Contribution to journal › Article › peer-review

Abstract

We measured directly the partial pressure of oxygen (pO₂) in new fibrosarcoma (NFSa) tumors grown in C3H/He mice using microcoaxial O₂ electrodes in vivo. The pO₂ in tumors was monitored after a single dose of X-ray or carbon-12 irradiation. After irradiation, tumor volume temporally shrinked, and pO₂ simultaneously increased. Carbon-12 irradiation reoxygenated tumors between the 1st and 9th day after the irradiation, while x-ray irradiation reoxygenated tumors between the 3rd and 8th day. We found that reoxygenation period after carbon-12 irradiation started earlier and continued longer than X-ray irradiation.

Original language	English
Pages (from-to)	371-372
Number of pages	2
Journal	American Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Volume	39
Publication status	Published - 1998 Dec 1

ASJC Scopus subject areas

Engineering(all)

Cite this

@article{0bbbc3e1847f4538a7cf4261da6d7a53,

title = "Reoxygenation in tumor tissues after X-ray or carbon-12 irradiation",

abstract = "We measured directly the partial pressure of oxygen (pO2) in new fibrosarcoma (NFSa) tumors grown in C3H/He mice using microcoaxial O2 electrodes in vivo. The pO2 in tumors was monitored after a single dose of X-ray or carbon-12 irradiation. After irradiation, tumor volume temporally shrinked, and pO2 simultaneously increased. Carbon-12 irradiation reoxygenated tumors between the 1st and 9th day after the irradiation, while x-ray irradiation reoxygenated tumors between the 3rd and 8th day. We found that reoxygenation period after carbon-12 irradiation started earlier and continued longer than X-ray irradiation.",

author = "Takeshi Fukawa and Koji Takematsu and Kotaro Oka and Nobuyuki Miyahara and Sachiko Koike and Koichi Ando and Hirosuke Kobayashi and Kazuo Tanishita",

year = "1998",

month = dec,

day = "1",

language = "English",

volume = "39",

pages = "371--372",

journal = "American Society of Mechanical Engineers, Bioengineering Division (Publication) BED",

issn = "1071-6947",

}

TY - JOUR

T1 - Reoxygenation in tumor tissues after X-ray or carbon-12 irradiation

AU - Fukawa, Takeshi

AU - Takematsu, Koji

AU - Oka, Kotaro

AU - Miyahara, Nobuyuki

AU - Koike, Sachiko

AU - Ando, Koichi

AU - Kobayashi, Hirosuke

AU - Tanishita, Kazuo

PY - 1998/12/1

Y1 - 1998/12/1

N2 - We measured directly the partial pressure of oxygen (pO2) in new fibrosarcoma (NFSa) tumors grown in C3H/He mice using microcoaxial O2 electrodes in vivo. The pO2 in tumors was monitored after a single dose of X-ray or carbon-12 irradiation. After irradiation, tumor volume temporally shrinked, and pO2 simultaneously increased. Carbon-12 irradiation reoxygenated tumors between the 1st and 9th day after the irradiation, while x-ray irradiation reoxygenated tumors between the 3rd and 8th day. We found that reoxygenation period after carbon-12 irradiation started earlier and continued longer than X-ray irradiation.

AB - We measured directly the partial pressure of oxygen (pO2) in new fibrosarcoma (NFSa) tumors grown in C3H/He mice using microcoaxial O2 electrodes in vivo. The pO2 in tumors was monitored after a single dose of X-ray or carbon-12 irradiation. After irradiation, tumor volume temporally shrinked, and pO2 simultaneously increased. Carbon-12 irradiation reoxygenated tumors between the 1st and 9th day after the irradiation, while x-ray irradiation reoxygenated tumors between the 3rd and 8th day. We found that reoxygenation period after carbon-12 irradiation started earlier and continued longer than X-ray irradiation.

UR - http://www.scopus.com/inward/record.url?scp=0032302996&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032302996&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0032302996

SN - 1071-6947

VL - 39

SP - 371

EP - 372

JO - American Society of Mechanical Engineers, Bioengineering Division (Publication) BED

JF - American Society of Mechanical Engineers, Bioengineering Division (Publication) BED

ER -

Reoxygenation in tumor tissues after X-ray or carbon-12 irradiation

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this