Repeated evening home blood pressure measurement improves prognostic significance for stroke: A 12-year follow-up of the ohasama study

Objective To compare the predictive power of home blood pressure (HBP) measured in the evening (E-HBP) and that of casual screening BP (CBP) for stroke risk in relation to the number of E-HBP measurements. Methods We obtained E-HBP (measured once in the evening just before going to bed for 4 weeks) and CBP (measured twice during the health checkup) from 2234 Japanese participants aged ^ 35 years who had no history of a previous stroke. The participants were followed-up for a median duration of 11.9 years. The multivariate adjusted relative hazard (RH) and 95% confidence intervals (CI) for each 10mmHg (systolic) or 5mmHg (diastolic) increase in BP was determined by Cox regression model. Results There were 226 incidences of stroke. Even the initial E-HBP values significantly predicted future stroke events (systolic RH = 1.19. 95% CI = 1.11-1.28; diastolic RH = 1.12. 95% CI = 1.06-1.19). and the predictive power of E-HBP increased progressively with the increased number of measurements. When initial systolic E-HBP and systolic CBP values were simultaneously included into the Cox model. only initial E-HBP was significantly related with stroke risk (E-HBP RH = 1.17. 95% CI = 1.08-1.26; CBP RH = 1.07. 95% CI=0.99-1.15). Conclusion E-HBP has a stronger predictive power than CBP regardless of the number of measurements. Our findings emphasize the important clinical significance of E-HBP over CBP. even though the measurement conditions of E-HBP are generally less strict than that of morning HBP measurements.