Repetitive trigeminal nociceptive stimulation in rats increases their susceptibility to cortical spreading depression

Haruki Toriumi, Toshihiko Shimizu, Taeko Ebine, Tsubasa Takizawa, Yohei Kayama, Anri Koh, Mamoru Shibata, Norihiro Suzuki

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4 Citations (Scopus)


We examined the ability of trigeminal nerve activation to induce cortical spreading depression in rats. Capsaicin was injected into the bilateral plantar or whisker pad for either 4 or 6 days in rats. The number and duration of cortical spreading depressions induced by potassium were significantly increased in animals injected with capsaicin in the bilateral whisker pad compared with animals injected in the bilateral plantar or in controls, while administration of a GABAA receptor agonist decreased these effects. Repetitive nociceptive stimulation of the trigeminal nerve lowers the threshold for the induction of cortical spreading depression by altering GABAergic neuronal activity.

Original languageEnglish
JournalNeuroscience Research
Publication statusAccepted/In press - 2015 Aug 11



  • Capsaicin
  • Cortical spreading depression
  • GABA
  • Nociceptive stimulation
  • Trigeminal nerve

ASJC Scopus subject areas

  • Neuroscience(all)

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